Association of ACE, ACE2 and UTS2 Polymorphisms with Essential Hypertension in Han and Dongxiang Populations from North-western China

To assess the significance of polymorphisms of the genes for angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2) and urotensin II (UTS2) as risk factors for essential hypertension in two populations from north-western China, we enrolled 198 patients with essential hypertensio...

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Bibliographic Details
Published in:Journal of international medical research 2006-05, Vol.34 (3), p.272-283
Main Authors: Yi, L, Gu, YH, Wang, XL, An, LZ, Xie, XD, Shao, W, Ma, LY, Fang, JR, An, YD, Wang, F, Zhang, DL
Format: Article
Language:English
Subjects:
Adult
Aged
Case-Control Studies
China
Female
Genetics, Population
Humans
Hypertension - enzymology
Hypertension - genetics
Male
Middle Aged
Peptidyl-Dipeptidase A - genetics
Polymorphism, Single Nucleotide
Risk Factors
Urotensins - genetics
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Summary:To assess the significance of polymorphisms of the genes for angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2) and urotensin II (UTS2) as risk factors for essential hypertension in two populations from north-western China, we enrolled 198 patients with essential hypertension and 131 healthy controls from the Han population and 120 patients with essential hypertension and 102 healthy controls from the Dongxiang population. Polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism were used to analyse gene polymorphisms. The results provided evidence that genetic variants of UTS2 and ACE2 may play a role in the development of essential hypertension in these populations. Polymorphisms of ACE were not associated with essential hypertension in either population. This is the first report showing that the S89N single-nucleotide polymorphism of the UTS2 gene is associated with essential hypertension.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323000603400306