Adrenomedullin in human male reproductive system

To investigate adrenomedullin (AM) localization and distribution in human male reproductive system and to determine whether seminal fluid AM concentration correlates with sperm parameters. Plasma and semen samples ( n = 19) obtained from healthy volunteers with normal seminal fluid parameters were a...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2005-10, Vol.122 (2), p.195-198
Main Authors: Marinoni, Emanuela, Iorio, Romolo Di, Villaccio, Barbara, Vellucci, Olga, Netta, Tiziana Di, Sessa, Mariateresa, Letizia, Claudio, Cosmi, Ermelando V.
Format: Article
Language:English
Subjects:
Adrenomedullin
Adult
Biological and medical sciences
Endothelial Cells - metabolism
Fertility - physiology
Gynecology. Andrology. Obstetrics
Humans
Leydig Cells - metabolism
Male
Male fertility
Medical sciences
Muscle Cells - metabolism
Penile Erection
Penis - cytology
Penis - metabolism
Peptides - blood
Peptides - metabolism
Plasma adrenomedullin
Semen
Semen - metabolism
Sertoli Cells - metabolism
Sperm Motility
Spermatocytes - metabolism
Testis
Testis - cytology
Testis - metabolism
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Summary:To investigate adrenomedullin (AM) localization and distribution in human male reproductive system and to determine whether seminal fluid AM concentration correlates with sperm parameters. Plasma and semen samples ( n = 19) obtained from healthy volunteers with normal seminal fluid parameters were assayed for AM using a specific RIA. AM immunostaining was sought on sections of penile cavernous bodies and testicular tissues obtained postmortem from four young males after accidental death using a polyclonal antibody to AM 1-52. Mean AM concentration in seminal plasma was 209.4 ± 46.6 pg/ml, 8–9-fold higher than in circulating plasma and correlated with sperm motility ( r = 0.715, p < 0.01). Endothelial cells of cavernous vessels stained for AM. Intense AM immunostaining was found in germinal cells and in peritubular myocytes and Leydig cells in the testis. These findings demonstrated for the first time that AM is localized in human male reproductive system. The local secretion of AM suggests that AM may contribute either in the penile erection and in the regulation of testicular function and sperm motility.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2005.03.021