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Adrenomedullin in human male reproductive system
To investigate adrenomedullin (AM) localization and distribution in human male reproductive system and to determine whether seminal fluid AM concentration correlates with sperm parameters. Plasma and semen samples ( n = 19) obtained from healthy volunteers with normal seminal fluid parameters were a...
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| Published in: | European journal of obstetrics & gynecology and reproductive biology 2005-10, Vol.122 (2), p.195-198 |
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| Main Authors: | , , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c390t-6c42035f44948232f3bcf70b14056c8b9e77829d1f3f4a0af6e83829db57af713 |
| container_end_page | 198 |
| container_issue | 2 |
| container_start_page | 195 |
| container_title | European journal of obstetrics & gynecology and reproductive biology |
| container_volume | 122 |
| creator | Marinoni, Emanuela Iorio, Romolo Di Villaccio, Barbara Vellucci, Olga Netta, Tiziana Di Sessa, Mariateresa Letizia, Claudio Cosmi, Ermelando V. |
| description | To investigate adrenomedullin (AM) localization and distribution in human male reproductive system and to determine whether seminal fluid AM concentration correlates with sperm parameters.
Plasma and semen samples (
n
=
19) obtained from healthy volunteers with normal seminal fluid parameters were assayed for AM using a specific RIA. AM immunostaining was sought on sections of penile cavernous bodies and testicular tissues obtained postmortem from four young males after accidental death using a polyclonal antibody to AM 1-52.
Mean AM concentration in seminal plasma was 209.4
±
46.6
pg/ml, 8–9-fold higher than in circulating plasma and correlated with sperm motility (
r
=
0.715,
p
<
0.01). Endothelial cells of cavernous vessels stained for AM. Intense AM immunostaining was found in germinal cells and in peritubular myocytes and Leydig cells in the testis.
These findings demonstrated for the first time that AM is localized in human male reproductive system. The local secretion of AM suggests that AM may contribute either in the penile erection and in the regulation of testicular function and sperm motility. |
| doi_str_mv | 10.1016/j.ejogrb.2005.03.021 |
| format | article |
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Plasma and semen samples (
n
=
19) obtained from healthy volunteers with normal seminal fluid parameters were assayed for AM using a specific RIA. AM immunostaining was sought on sections of penile cavernous bodies and testicular tissues obtained postmortem from four young males after accidental death using a polyclonal antibody to AM 1-52.
Mean AM concentration in seminal plasma was 209.4
±
46.6
pg/ml, 8–9-fold higher than in circulating plasma and correlated with sperm motility (
r
=
0.715,
p
<
0.01). Endothelial cells of cavernous vessels stained for AM. Intense AM immunostaining was found in germinal cells and in peritubular myocytes and Leydig cells in the testis.
These findings demonstrated for the first time that AM is localized in human male reproductive system. The local secretion of AM suggests that AM may contribute either in the penile erection and in the regulation of testicular function and sperm motility.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2005.03.021</identifier><identifier>PMID: 15908101</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adrenomedullin ; Adult ; Biological and medical sciences ; Endothelial Cells - metabolism ; Fertility - physiology ; Gynecology. Andrology. Obstetrics ; Humans ; Leydig Cells - metabolism ; Male ; Male fertility ; Medical sciences ; Muscle Cells - metabolism ; Penile Erection ; Penis - cytology ; Penis - metabolism ; Peptides - blood ; Peptides - metabolism ; Plasma adrenomedullin ; Semen ; Semen - metabolism ; Sertoli Cells - metabolism ; Sperm Motility ; Spermatocytes - metabolism ; Testis ; Testis - cytology ; Testis - metabolism</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2005-10, Vol.122 (2), p.195-198</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-6c42035f44948232f3bcf70b14056c8b9e77829d1f3f4a0af6e83829db57af713</citedby><cites>FETCH-LOGICAL-c390t-6c42035f44948232f3bcf70b14056c8b9e77829d1f3f4a0af6e83829db57af713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17192391$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15908101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marinoni, Emanuela</creatorcontrib><creatorcontrib>Iorio, Romolo Di</creatorcontrib><creatorcontrib>Villaccio, Barbara</creatorcontrib><creatorcontrib>Vellucci, Olga</creatorcontrib><creatorcontrib>Netta, Tiziana Di</creatorcontrib><creatorcontrib>Sessa, Mariateresa</creatorcontrib><creatorcontrib>Letizia, Claudio</creatorcontrib><creatorcontrib>Cosmi, Ermelando V.</creatorcontrib><title>Adrenomedullin in human male reproductive system</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>To investigate adrenomedullin (AM) localization and distribution in human male reproductive system and to determine whether seminal fluid AM concentration correlates with sperm parameters.
Plasma and semen samples (
n
=
19) obtained from healthy volunteers with normal seminal fluid parameters were assayed for AM using a specific RIA. AM immunostaining was sought on sections of penile cavernous bodies and testicular tissues obtained postmortem from four young males after accidental death using a polyclonal antibody to AM 1-52.
Mean AM concentration in seminal plasma was 209.4
±
46.6
pg/ml, 8–9-fold higher than in circulating plasma and correlated with sperm motility (
r
=
0.715,
p
<
0.01). Endothelial cells of cavernous vessels stained for AM. Intense AM immunostaining was found in germinal cells and in peritubular myocytes and Leydig cells in the testis.
These findings demonstrated for the first time that AM is localized in human male reproductive system. The local secretion of AM suggests that AM may contribute either in the penile erection and in the regulation of testicular function and sperm motility.</description><subject>Adrenomedullin</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Endothelial Cells - metabolism</subject><subject>Fertility - physiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Leydig Cells - metabolism</subject><subject>Male</subject><subject>Male fertility</subject><subject>Medical sciences</subject><subject>Muscle Cells - metabolism</subject><subject>Penile Erection</subject><subject>Penis - cytology</subject><subject>Penis - metabolism</subject><subject>Peptides - blood</subject><subject>Peptides - metabolism</subject><subject>Plasma adrenomedullin</subject><subject>Semen</subject><subject>Semen - metabolism</subject><subject>Sertoli Cells - metabolism</subject><subject>Sperm Motility</subject><subject>Spermatocytes - metabolism</subject><subject>Testis</subject><subject>Testis - cytology</subject><subject>Testis - metabolism</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMo7rr6D0T2orfWSdI27UVYFr9gwYueQ5pONEs_1qRd2H9vyhb2ZhgIDM-8zDyE3FKIKdDscRvjtvt2ZcwA0hh4DIyekTnNBYtElibnZA4caMQoTWfkyvsthMd5cUlmNC0gDylzAqvKYds1WA11bdtlqJ-hUe2yUTUuHe5cVw26t3tc-oPvsbkmF0bVHm-mf0G-Xp4_12_R5uP1fb3aRJoX0EeZThjw1CRJkeSMM8NLbQSUNIE003lZoBA5KypquEkUKJNhzsdGmQplBOUL8nDMDRv8Duh72Vivsa5Vi93gZZZnORXpCCZHULvOe4dG7pxtlDtICnI0JbfyaEqOpiRwGUyFsbspfyjD9aehSU0A7idAea1q41SrrT9xghaMFyP3dOQw2NhbdNJri63GyjrUvaw6-_8mf141h0o</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Marinoni, Emanuela</creator><creator>Iorio, Romolo Di</creator><creator>Villaccio, Barbara</creator><creator>Vellucci, Olga</creator><creator>Netta, Tiziana Di</creator><creator>Sessa, Mariateresa</creator><creator>Letizia, Claudio</creator><creator>Cosmi, Ermelando V.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Adrenomedullin in human male reproductive system</title><author>Marinoni, Emanuela ; Iorio, Romolo Di ; Villaccio, Barbara ; Vellucci, Olga ; Netta, Tiziana Di ; Sessa, Mariateresa ; Letizia, Claudio ; Cosmi, Ermelando V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-6c42035f44948232f3bcf70b14056c8b9e77829d1f3f4a0af6e83829db57af713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenomedullin</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Endothelial Cells - metabolism</topic><topic>Fertility - physiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Leydig Cells - metabolism</topic><topic>Male</topic><topic>Male fertility</topic><topic>Medical sciences</topic><topic>Muscle Cells - metabolism</topic><topic>Penile Erection</topic><topic>Penis - cytology</topic><topic>Penis - metabolism</topic><topic>Peptides - blood</topic><topic>Peptides - metabolism</topic><topic>Plasma adrenomedullin</topic><topic>Semen</topic><topic>Semen - metabolism</topic><topic>Sertoli Cells - metabolism</topic><topic>Sperm Motility</topic><topic>Spermatocytes - metabolism</topic><topic>Testis</topic><topic>Testis - cytology</topic><topic>Testis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marinoni, Emanuela</creatorcontrib><creatorcontrib>Iorio, Romolo Di</creatorcontrib><creatorcontrib>Villaccio, Barbara</creatorcontrib><creatorcontrib>Vellucci, Olga</creatorcontrib><creatorcontrib>Netta, Tiziana Di</creatorcontrib><creatorcontrib>Sessa, Mariateresa</creatorcontrib><creatorcontrib>Letizia, Claudio</creatorcontrib><creatorcontrib>Cosmi, Ermelando V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marinoni, Emanuela</au><au>Iorio, Romolo Di</au><au>Villaccio, Barbara</au><au>Vellucci, Olga</au><au>Netta, Tiziana Di</au><au>Sessa, Mariateresa</au><au>Letizia, Claudio</au><au>Cosmi, Ermelando V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adrenomedullin in human male reproductive system</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>122</volume><issue>2</issue><spage>195</spage><epage>198</epage><pages>195-198</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract>To investigate adrenomedullin (AM) localization and distribution in human male reproductive system and to determine whether seminal fluid AM concentration correlates with sperm parameters.
Plasma and semen samples (
n
=
19) obtained from healthy volunteers with normal seminal fluid parameters were assayed for AM using a specific RIA. AM immunostaining was sought on sections of penile cavernous bodies and testicular tissues obtained postmortem from four young males after accidental death using a polyclonal antibody to AM 1-52.
Mean AM concentration in seminal plasma was 209.4
±
46.6
pg/ml, 8–9-fold higher than in circulating plasma and correlated with sperm motility (
r
=
0.715,
p
<
0.01). Endothelial cells of cavernous vessels stained for AM. Intense AM immunostaining was found in germinal cells and in peritubular myocytes and Leydig cells in the testis.
These findings demonstrated for the first time that AM is localized in human male reproductive system. The local secretion of AM suggests that AM may contribute either in the penile erection and in the regulation of testicular function and sperm motility.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15908101</pmid><doi>10.1016/j.ejogrb.2005.03.021</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-2115 |
| ispartof | European journal of obstetrics & gynecology and reproductive biology, 2005-10, Vol.122 (2), p.195-198 |
| issn | 0301-2115 1872-7654 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68681751 |
| source | ScienceDirect Journals |
| subjects | Adrenomedullin Adult Biological and medical sciences Endothelial Cells - metabolism Fertility - physiology Gynecology. Andrology. Obstetrics Humans Leydig Cells - metabolism Male Male fertility Medical sciences Muscle Cells - metabolism Penile Erection Penis - cytology Penis - metabolism Peptides - blood Peptides - metabolism Plasma adrenomedullin Semen Semen - metabolism Sertoli Cells - metabolism Sperm Motility Spermatocytes - metabolism Testis Testis - cytology Testis - metabolism |
| title | Adrenomedullin in human male reproductive system |
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