Association between immunohistochemical expression of topoisomerase IIalpha, HER2 and hormone receptors and response to primary chemotherapy in breast cancer

The aim of this study was to evaluate the association between immunohistochemical expression of topoisomerase IIalpha, HER2 and hormone receptors and response to primary anthracycline-based chemotherapy in locally advanced breast cancer. We analyzed 109 medical charts of patients treated with primar...

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Bibliographic Details
Published in:Tumori 2006-05, Vol.92 (3), p.222-229
Main Authors: Manna, Eliza Del Fiol, Teixeira, Luiz Carlos, Alvarenga, Marcelo
Format: Article
Language:English
Subjects:
Adult
Anthracyclines - administration & dosage
Antigens, Neoplasm - analysis
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers, Tumor - analysis
Brazil
Breast Neoplasms - chemistry
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - chemistry
Carcinoma, Ductal, Breast - drug therapy
DNA Topoisomerases, Type II - analysis
DNA-Binding Proteins - analysis
Female
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Medical Records
Middle Aged
Predictive Value of Tests
Receptor, ErbB-2 - analysis
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Retrospective Studies
Treatment Outcome
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Summary:The aim of this study was to evaluate the association between immunohistochemical expression of topoisomerase IIalpha, HER2 and hormone receptors and response to primary anthracycline-based chemotherapy in locally advanced breast cancer. We analyzed 109 medical charts of patients treated with primary anthracycline-based chemotherapy in the Women's Integral Health Care Center from 1996 to 2004. The clinical and pathological response to primary chemotherapy was associated with topoisomerase Ilalpha and HER2 expression and hormone receptor negativity. Statistical analysis was performed using chi-squared, Fisher's exact test and Mann-Whitney test. No statistical association between clinical response and expression of topoisomerase Ilalpha, HER2 and hormone receptor negativity was found. However, there was an association between complete pathological response and hormone receptor negativity (P = 0.0289). The present study suggested that these markers should not be considered predictors of response to primary anthracycline-based chemotherapy, and prospective studies must be designed for this purpose.
ISSN:0300-8916