Abdominal obesity and smoking are important determinants of C-reactive protein in renal transplant recipients

Background. C-reactive protein (CRP) is a predictor of coronary heart disease, total mortality and chronic allograft nephropathy in renal transplant recipients. The determinants of CRP have been investigated in the general population, but not in renal transplant recipients. CRP might reflect metabol...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2005-11, Vol.20 (11), p.2524-2531
Main Authors: van Ree, Rutger M., de Vries, Aiko P. J., Oterdoom, Leendert H., The, T. Hauw, Gansevoort, Ron T., Homan van der Heide, Jaap J., van Son, Willem J., Ploeg, Rutger J., de Jong, Paul E., Gans, Reinold O. B., Bakker, Stephan J. L.
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Biomarkers - blood
Body Mass Index
C-reactive protein
C-Reactive Protein - metabolism
Cardiovascular Diseases - blood
Cardiovascular Diseases - etiology
cardiovascular risk
chronic allograft nephropathy
Chronic Disease
Creatinine - blood
Emergency and intensive care: renal failure. Dialysis management
Female
Follow-Up Studies
Graft Rejection - blood
Graft Rejection - complications
Graft Rejection - prevention & control
Humans
Immunosuppressive Agents - therapeutic use
Intensive care medicine
Kidney Transplantation
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
obesity
Obesity - blood
Obesity - complications
Prognosis
Renal failure
renal transplantation
Retrospective Studies
Risk Factors
smoking
Smoking - adverse effects
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
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Summary:Background. C-reactive protein (CRP) is a predictor of coronary heart disease, total mortality and chronic allograft nephropathy in renal transplant recipients. The determinants of CRP have been investigated in the general population, but not in renal transplant recipients. CRP might reflect metabolic aberrations in association with central obesity and systemic atherosclerosis. However, it may also reflect a low-grade immune-mediated response to the graft. In this study we investigated the factors associated with CRP in a renal transplant population. Methods. Between August 2001 and July 2003, renal transplant recipients with a functioning graft for more than 1 year (n = 847) were eligible for investigation at their next visit to the outpatient clinic. A total of 606 patients (55% male, aged 51±12 years) participated at a median (interquartile range) time of 6.0 (2.6–11.4) years post-transplant. Results. Median CRP concentration was 2.0 (0.80–4.8) mg/l and mean 24 h creatinine clearance was 62±22 ml/min. CRP was significantly associated with body mass index, waist circumference and waist-to-hip ratio (P-value
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfi052