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Trends in Serum Lipids and Lipoproteins of Adults, 1960-2002
CONTEXT Serum total and low-density lipoprotein (LDL) cholesterol contribute significantly to atherosclerosis and its clinical sequelae. Previous analyses of data from the National Health and Nutrition Examination Surveys (NHANES) showed that mean levels of total cholesterol of US adults had decline...
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| Published in: | JAMA : the journal of the American Medical Association 2005-10, Vol.294 (14), p.1773-1781 |
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| container_title | JAMA : the journal of the American Medical Association |
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| creator | Carroll, Margaret D Lacher, David A Sorlie, Paul D Cleeman, James I Gordon, David J Wolz, Michael Grundy, Scott M Johnson, Clifford L |
| description | CONTEXT Serum total and low-density lipoprotein (LDL) cholesterol contribute
significantly to atherosclerosis and its clinical sequelae. Previous analyses
of data from the National Health and Nutrition Examination Surveys (NHANES)
showed that mean levels of total cholesterol of US adults had declined from
1960-1962 to 1988-1994, and mean levels of LDL cholesterol (available beginning
in 1976) had declined between 1976-1980 and 1988-1994. OBJECTIVE To examine trends in serum lipid levels among US adults between 1960
and 2002, with a particular focus on changes since the 1988-1994 NHANES survey. DESIGN, SETTING, AND PARTICIPANTS Blood lipid measurements taken from 6098 to 15 719 adults who were
examined in 5 distinct cross-sectional surveys of the US population during
1960-1962, 1971-1974, 1976-1980, 1988-1994, and 1999-2002. MAIN OUTCOME MEASURES Mean serum total cholesterol, LDL cholesterol, high-density lipoprotein
(HDL) cholesterol, and geometric mean serum triglyceride levels, and the percentage
of adults with a serum total cholesterol level of at least 240 mg/dL (≥6.22
mmol/L). RESULTS Between 1988-1994 and 1999-2002, total serum cholesterol level of adults
aged 20 years or older decreased from 206 mg/dL (5.34 mmol/L) to 203 mg/dL
(5.26 mmol/L) (P=.009) and LDL cholesterol levels
decreased from 129 mg/dL (3.34 mmol/L) to 123 mg/dL (3.19 mmol/L) (P |
| doi_str_mv | 10.1001/jama.294.14.1773 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68683831</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>201671</ama_id><sourcerecordid>911519031</sourcerecordid><originalsourceid>FETCH-LOGICAL-a373t-f79780c5d53da4a2d760e8de11804110d7c0dcf6e8b906baf05ab60d7ad97e603</originalsourceid><addsrcrecordid>eNpdkUtLw0AQxxdRbK3e9SJB0JOpM9nsC7wU8QUFD9ZzmGQ3kJJHzSYHv71bWhUcBub1488ww9g5whwB8G5NDc0Tk84xuFL8gE1RcB1zYfQhmwIYHatUpxN24v0agiFXx2yCMkGjNUzZ_ap3rfVR1Ubvrh-baFltqlBTa7dpt-m7wVWtj7oyWtixHvxthEZCnAAkp-yopNq7s32csY-nx9XDS7x8e359WCxj4ooPcamM0lAIK7illBKrJDhtHaKGFBGsKsAWpXQ6NyBzKkFQLkObrFFOAp-xm51u2OZzdH7ImsoXrq6pdd3oM6ml5ppjAK_-getu7NuwW5YgcgECZIAu99CYN85mm75qqP_Kfo4SgOs9QL6guuypLSr_xykUkqut0MWOC1_4nSaAUiH_BsxtdZo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211350506</pqid></control><display><type>article</type><title>Trends in Serum Lipids and Lipoproteins of Adults, 1960-2002</title><source>AMA Current Titles</source><creator>Carroll, Margaret D ; Lacher, David A ; Sorlie, Paul D ; Cleeman, James I ; Gordon, David J ; Wolz, Michael ; Grundy, Scott M ; Johnson, Clifford L</creator><creatorcontrib>Carroll, Margaret D ; Lacher, David A ; Sorlie, Paul D ; Cleeman, James I ; Gordon, David J ; Wolz, Michael ; Grundy, Scott M ; Johnson, Clifford L</creatorcontrib><description>CONTEXT Serum total and low-density lipoprotein (LDL) cholesterol contribute
significantly to atherosclerosis and its clinical sequelae. Previous analyses
of data from the National Health and Nutrition Examination Surveys (NHANES)
showed that mean levels of total cholesterol of US adults had declined from
1960-1962 to 1988-1994, and mean levels of LDL cholesterol (available beginning
in 1976) had declined between 1976-1980 and 1988-1994. OBJECTIVE To examine trends in serum lipid levels among US adults between 1960
and 2002, with a particular focus on changes since the 1988-1994 NHANES survey. DESIGN, SETTING, AND PARTICIPANTS Blood lipid measurements taken from 6098 to 15 719 adults who were
examined in 5 distinct cross-sectional surveys of the US population during
1960-1962, 1971-1974, 1976-1980, 1988-1994, and 1999-2002. MAIN OUTCOME MEASURES Mean serum total cholesterol, LDL cholesterol, high-density lipoprotein
(HDL) cholesterol, and geometric mean serum triglyceride levels, and the percentage
of adults with a serum total cholesterol level of at least 240 mg/dL (≥6.22
mmol/L). RESULTS Between 1988-1994 and 1999-2002, total serum cholesterol level of adults
aged 20 years or older decreased from 206 mg/dL (5.34 mmol/L) to 203 mg/dL
(5.26 mmol/L) (P=.009) and LDL cholesterol levels
decreased from 129 mg/dL (3.34 mmol/L) to 123 mg/dL (3.19 mmol/L) (P<.001). Greater and significant decreases were observed in men
60 years or older and in women 50 years or older. The percentage of adults
with a total cholesterol level of at least 240 mg/dL (≥6.22 mmol/L) decreased
from 20% during 1988-1994 to 17% during 1999-2002 (P<.001).
There was no change in mean HDL cholesterol levels and a nonsignificant increase
in geometric mean serum triglyceride levels (P = .06). CONCLUSIONS The decrease in total cholesterol level observed during 1960-1994 and
LDL cholesterol level observed during 1976-1994 has continued during 1999-2002
in men 60 to 74 years and women 50 to 74 years. The target value of no more
than 17% of US adults with a total cholesterol level of at least 240 mg/dL
(≥6.22 mmol/L), an objective of Healthy People 2010,
has been attained. The increase in the proportion of adults using lipid-lowering
medication, particularly in older age groups, likely contributed to the decreases
in total and LDL cholesterol levels observed. The increased prevalence of
obesity in the US population may have contributed to the increase in mean
serum triglyceride levels.</description><identifier>ISSN: 0098-7484</identifier><identifier>EISSN: 1538-3598</identifier><identifier>DOI: 10.1001/jama.294.14.1773</identifier><identifier>PMID: 16219880</identifier><identifier>CODEN: JAMAAP</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adult ; Adults ; Aged ; Biological and medical sciences ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cross-Sectional Studies ; Drug Utilization ; Female ; General aspects ; Health Status ; Humans ; Hyperlipoproteinemias - epidemiology ; Hypolipidemic Agents - therapeutic use ; Life Style ; Lipids ; Lipoproteins - blood ; Low density lipoprotein ; Male ; Medical sciences ; Medical statistics ; Middle Aged ; Nutrition Surveys ; Obesity - epidemiology ; Triglycerides - blood ; United States - epidemiology</subject><ispartof>JAMA : the journal of the American Medical Association, 2005-10, Vol.294 (14), p.1773-1781</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright American Medical Association Oct 12, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a373t-f79780c5d53da4a2d760e8de11804110d7c0dcf6e8b906baf05ab60d7ad97e603</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17156376$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16219880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carroll, Margaret D</creatorcontrib><creatorcontrib>Lacher, David A</creatorcontrib><creatorcontrib>Sorlie, Paul D</creatorcontrib><creatorcontrib>Cleeman, James I</creatorcontrib><creatorcontrib>Gordon, David J</creatorcontrib><creatorcontrib>Wolz, Michael</creatorcontrib><creatorcontrib>Grundy, Scott M</creatorcontrib><creatorcontrib>Johnson, Clifford L</creatorcontrib><title>Trends in Serum Lipids and Lipoproteins of Adults, 1960-2002</title><title>JAMA : the journal of the American Medical Association</title><addtitle>JAMA</addtitle><description>CONTEXT Serum total and low-density lipoprotein (LDL) cholesterol contribute
significantly to atherosclerosis and its clinical sequelae. Previous analyses
of data from the National Health and Nutrition Examination Surveys (NHANES)
showed that mean levels of total cholesterol of US adults had declined from
1960-1962 to 1988-1994, and mean levels of LDL cholesterol (available beginning
in 1976) had declined between 1976-1980 and 1988-1994. OBJECTIVE To examine trends in serum lipid levels among US adults between 1960
and 2002, with a particular focus on changes since the 1988-1994 NHANES survey. DESIGN, SETTING, AND PARTICIPANTS Blood lipid measurements taken from 6098 to 15 719 adults who were
examined in 5 distinct cross-sectional surveys of the US population during
1960-1962, 1971-1974, 1976-1980, 1988-1994, and 1999-2002. MAIN OUTCOME MEASURES Mean serum total cholesterol, LDL cholesterol, high-density lipoprotein
(HDL) cholesterol, and geometric mean serum triglyceride levels, and the percentage
of adults with a serum total cholesterol level of at least 240 mg/dL (≥6.22
mmol/L). RESULTS Between 1988-1994 and 1999-2002, total serum cholesterol level of adults
aged 20 years or older decreased from 206 mg/dL (5.34 mmol/L) to 203 mg/dL
(5.26 mmol/L) (P=.009) and LDL cholesterol levels
decreased from 129 mg/dL (3.34 mmol/L) to 123 mg/dL (3.19 mmol/L) (P<.001). Greater and significant decreases were observed in men
60 years or older and in women 50 years or older. The percentage of adults
with a total cholesterol level of at least 240 mg/dL (≥6.22 mmol/L) decreased
from 20% during 1988-1994 to 17% during 1999-2002 (P<.001).
There was no change in mean HDL cholesterol levels and a nonsignificant increase
in geometric mean serum triglyceride levels (P = .06). CONCLUSIONS The decrease in total cholesterol level observed during 1960-1994 and
LDL cholesterol level observed during 1976-1994 has continued during 1999-2002
in men 60 to 74 years and women 50 to 74 years. The target value of no more
than 17% of US adults with a total cholesterol level of at least 240 mg/dL
(≥6.22 mmol/L), an objective of Healthy People 2010,
has been attained. The increase in the proportion of adults using lipid-lowering
medication, particularly in older age groups, likely contributed to the decreases
in total and LDL cholesterol levels observed. The increased prevalence of
obesity in the US population may have contributed to the increase in mean
serum triglyceride levels.</description><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>Drug Utilization</subject><subject>Female</subject><subject>General aspects</subject><subject>Health Status</subject><subject>Humans</subject><subject>Hyperlipoproteinemias - epidemiology</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>Life Style</subject><subject>Lipids</subject><subject>Lipoproteins - blood</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical statistics</subject><subject>Middle Aged</subject><subject>Nutrition Surveys</subject><subject>Obesity - epidemiology</subject><subject>Triglycerides - blood</subject><subject>United States - epidemiology</subject><issn>0098-7484</issn><issn>1538-3598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpdkUtLw0AQxxdRbK3e9SJB0JOpM9nsC7wU8QUFD9ZzmGQ3kJJHzSYHv71bWhUcBub1488ww9g5whwB8G5NDc0Tk84xuFL8gE1RcB1zYfQhmwIYHatUpxN24v0agiFXx2yCMkGjNUzZ_ap3rfVR1Ubvrh-baFltqlBTa7dpt-m7wVWtj7oyWtixHvxthEZCnAAkp-yopNq7s32csY-nx9XDS7x8e359WCxj4ooPcamM0lAIK7illBKrJDhtHaKGFBGsKsAWpXQ6NyBzKkFQLkObrFFOAp-xm51u2OZzdH7ImsoXrq6pdd3oM6ml5ppjAK_-getu7NuwW5YgcgECZIAu99CYN85mm75qqP_Kfo4SgOs9QL6guuypLSr_xykUkqut0MWOC1_4nSaAUiH_BsxtdZo</recordid><startdate>20051012</startdate><enddate>20051012</enddate><creator>Carroll, Margaret D</creator><creator>Lacher, David A</creator><creator>Sorlie, Paul D</creator><creator>Cleeman, James I</creator><creator>Gordon, David J</creator><creator>Wolz, Michael</creator><creator>Grundy, Scott M</creator><creator>Johnson, Clifford L</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20051012</creationdate><title>Trends in Serum Lipids and Lipoproteins of Adults, 1960-2002</title><author>Carroll, Margaret D ; Lacher, David A ; Sorlie, Paul D ; Cleeman, James I ; Gordon, David J ; Wolz, Michael ; Grundy, Scott M ; Johnson, Clifford L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a373t-f79780c5d53da4a2d760e8de11804110d7c0dcf6e8b906baf05ab60d7ad97e603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cross-Sectional Studies</topic><topic>Drug Utilization</topic><topic>Female</topic><topic>General aspects</topic><topic>Health Status</topic><topic>Humans</topic><topic>Hyperlipoproteinemias - epidemiology</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>Life Style</topic><topic>Lipids</topic><topic>Lipoproteins - blood</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical statistics</topic><topic>Middle Aged</topic><topic>Nutrition Surveys</topic><topic>Obesity - epidemiology</topic><topic>Triglycerides - blood</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carroll, Margaret D</creatorcontrib><creatorcontrib>Lacher, David A</creatorcontrib><creatorcontrib>Sorlie, Paul D</creatorcontrib><creatorcontrib>Cleeman, James I</creatorcontrib><creatorcontrib>Gordon, David J</creatorcontrib><creatorcontrib>Wolz, Michael</creatorcontrib><creatorcontrib>Grundy, Scott M</creatorcontrib><creatorcontrib>Johnson, Clifford L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>JAMA : the journal of the American Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carroll, Margaret D</au><au>Lacher, David A</au><au>Sorlie, Paul D</au><au>Cleeman, James I</au><au>Gordon, David J</au><au>Wolz, Michael</au><au>Grundy, Scott M</au><au>Johnson, Clifford L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trends in Serum Lipids and Lipoproteins of Adults, 1960-2002</atitle><jtitle>JAMA : the journal of the American Medical Association</jtitle><addtitle>JAMA</addtitle><date>2005-10-12</date><risdate>2005</risdate><volume>294</volume><issue>14</issue><spage>1773</spage><epage>1781</epage><pages>1773-1781</pages><issn>0098-7484</issn><eissn>1538-3598</eissn><coden>JAMAAP</coden><abstract>CONTEXT Serum total and low-density lipoprotein (LDL) cholesterol contribute
significantly to atherosclerosis and its clinical sequelae. Previous analyses
of data from the National Health and Nutrition Examination Surveys (NHANES)
showed that mean levels of total cholesterol of US adults had declined from
1960-1962 to 1988-1994, and mean levels of LDL cholesterol (available beginning
in 1976) had declined between 1976-1980 and 1988-1994. OBJECTIVE To examine trends in serum lipid levels among US adults between 1960
and 2002, with a particular focus on changes since the 1988-1994 NHANES survey. DESIGN, SETTING, AND PARTICIPANTS Blood lipid measurements taken from 6098 to 15 719 adults who were
examined in 5 distinct cross-sectional surveys of the US population during
1960-1962, 1971-1974, 1976-1980, 1988-1994, and 1999-2002. MAIN OUTCOME MEASURES Mean serum total cholesterol, LDL cholesterol, high-density lipoprotein
(HDL) cholesterol, and geometric mean serum triglyceride levels, and the percentage
of adults with a serum total cholesterol level of at least 240 mg/dL (≥6.22
mmol/L). RESULTS Between 1988-1994 and 1999-2002, total serum cholesterol level of adults
aged 20 years or older decreased from 206 mg/dL (5.34 mmol/L) to 203 mg/dL
(5.26 mmol/L) (P=.009) and LDL cholesterol levels
decreased from 129 mg/dL (3.34 mmol/L) to 123 mg/dL (3.19 mmol/L) (P<.001). Greater and significant decreases were observed in men
60 years or older and in women 50 years or older. The percentage of adults
with a total cholesterol level of at least 240 mg/dL (≥6.22 mmol/L) decreased
from 20% during 1988-1994 to 17% during 1999-2002 (P<.001).
There was no change in mean HDL cholesterol levels and a nonsignificant increase
in geometric mean serum triglyceride levels (P = .06). CONCLUSIONS The decrease in total cholesterol level observed during 1960-1994 and
LDL cholesterol level observed during 1976-1994 has continued during 1999-2002
in men 60 to 74 years and women 50 to 74 years. The target value of no more
than 17% of US adults with a total cholesterol level of at least 240 mg/dL
(≥6.22 mmol/L), an objective of Healthy People 2010,
has been attained. The increase in the proportion of adults using lipid-lowering
medication, particularly in older age groups, likely contributed to the decreases
in total and LDL cholesterol levels observed. The increased prevalence of
obesity in the US population may have contributed to the increase in mean
serum triglyceride levels.</abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>16219880</pmid><doi>10.1001/jama.294.14.1773</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0098-7484 |
| ispartof | JAMA : the journal of the American Medical Association, 2005-10, Vol.294 (14), p.1773-1781 |
| issn | 0098-7484 1538-3598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68683831 |
| source | AMA Current Titles |
| subjects | Adult Adults Aged Biological and medical sciences Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Cross-Sectional Studies Drug Utilization Female General aspects Health Status Humans Hyperlipoproteinemias - epidemiology Hypolipidemic Agents - therapeutic use Life Style Lipids Lipoproteins - blood Low density lipoprotein Male Medical sciences Medical statistics Middle Aged Nutrition Surveys Obesity - epidemiology Triglycerides - blood United States - epidemiology |
| title | Trends in Serum Lipids and Lipoproteins of Adults, 1960-2002 |
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