Reduction of N terminal-pro-brain (B-type) natriuretic peptide levels with exercise-based cardiac rehabilitation in patients with left ventricular dysfunction after myocardial infarction

Introduction N-terminal-pro-brain (B-type) natriuretic peptide (NT-pro-BNP) is a peptide hormone released from ventricles in response to myocyte stretch. The aim of the study was to investigate the influence of exercise training on plasma NT-pro-BNP to verify if this parameter could be used as a bio...

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Published in:European journal of cardiovascular prevention and rehabilitation 2006-08, Vol.13 (4), p.625-632
Main Authors: Giallauria, Francesco, Lorenzo, Anna De, Pilerci, Francesco, Manakos, Athanasio, Lucci, Rosa, Psaroudaki, Marianna, D'Agostino, Mariantonietta, Forno, Domenico Del, Vigorito, Carlo
Format: Article
Language:English
Subjects:
Biomarkers - blood
Echocardiography, Doppler, Pulsed
Exercise - physiology
Exercise Therapy - methods
Female
Heart Ventricles - diagnostic imaging
Heart Ventricles - metabolism
Heart Ventricles - physiopathology
Humans
Male
Middle Aged
Myocardial Contraction - physiology
Myocardial Infarction - blood
Myocardial Infarction - complications
Myocardial Infarction - physiopathology
Natriuretic Peptide, Brain - blood
Treatment Outcome
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Left - rehabilitation
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Summary:Introduction N-terminal-pro-brain (B-type) natriuretic peptide (NT-pro-BNP) is a peptide hormone released from ventricles in response to myocyte stretch. The aim of the study was to investigate the influence of exercise training on plasma NT-pro-BNP to verify if this parameter could be used as a biological marker of left ventricular remodelling in myocardial infarction patients undergoing an exercise training programme. Methods Forty-four patients after myocardial infarction were enrolled into a cardiac rehabilitation programme, and were randomized in two groups of 22 patients each. Group A patients followed a 3-month exercise training programme, while group B patients received only routine recommendations. All patients underwent NT-pro-BNP assay, and cardiopulmonary exercise test before hospital discharge and after 3 months. Results In Group A, exercise training reduced NT-pro-BNP levels (from 1498 ± 438 to 470 ± 375 pg/ml, P = 0.0026), increased maximal (V O2peak + 4.3 ± 2.9 ml/kg per min, P
ISSN:2047-4873
1741-8267
2047-4881
DOI:10.1097/01.hjr.0000209810.59831.f4