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Reduction of N terminal-pro-brain (B-type) natriuretic peptide levels with exercise-based cardiac rehabilitation in patients with left ventricular dysfunction after myocardial infarction
Introduction N-terminal-pro-brain (B-type) natriuretic peptide (NT-pro-BNP) is a peptide hormone released from ventricles in response to myocyte stretch. The aim of the study was to investigate the influence of exercise training on plasma NT-pro-BNP to verify if this parameter could be used as a bio...
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| Published in: | European journal of cardiovascular prevention and rehabilitation 2006-08, Vol.13 (4), p.625-632 |
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| container_title | European journal of cardiovascular prevention and rehabilitation |
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| creator | Giallauria, Francesco Lorenzo, Anna De Pilerci, Francesco Manakos, Athanasio Lucci, Rosa Psaroudaki, Marianna D'Agostino, Mariantonietta Forno, Domenico Del Vigorito, Carlo |
| description | Introduction
N-terminal-pro-brain (B-type) natriuretic peptide (NT-pro-BNP) is a peptide hormone released from ventricles in response to myocyte stretch. The aim of the study was to investigate the influence of exercise training on plasma NT-pro-BNP to verify if this parameter could be used as a biological marker of left ventricular remodelling in myocardial infarction patients undergoing an exercise training programme.
Methods
Forty-four patients after myocardial infarction were enrolled into a cardiac rehabilitation programme, and were randomized in two groups of 22 patients each. Group A patients followed a 3-month exercise training programme, while group B patients received only routine recommendations. All patients underwent NT-pro-BNP assay, and cardiopulmonary exercise test before hospital discharge and after 3 months.
Results
In Group A, exercise training reduced NT-pro-BNP levels (from 1498 ± 438 to 470 ± 375 pg/ml, P = 0.0026), increased maximal (V
O2peak + 4.3 ± 2.9 ml/kg per min, P |
| doi_str_mv | 10.1097/01.hjr.0000209810.59831.f4 |
| format | article |
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N-terminal-pro-brain (B-type) natriuretic peptide (NT-pro-BNP) is a peptide hormone released from ventricles in response to myocyte stretch. The aim of the study was to investigate the influence of exercise training on plasma NT-pro-BNP to verify if this parameter could be used as a biological marker of left ventricular remodelling in myocardial infarction patients undergoing an exercise training programme.
Methods
Forty-four patients after myocardial infarction were enrolled into a cardiac rehabilitation programme, and were randomized in two groups of 22 patients each. Group A patients followed a 3-month exercise training programme, while group B patients received only routine recommendations. All patients underwent NT-pro-BNP assay, and cardiopulmonary exercise test before hospital discharge and after 3 months.
Results
In Group A, exercise training reduced NT-pro-BNP levels (from 1498 ± 438 to 470 ± 375 pg/ml, P = 0.0026), increased maximal (V
O2peak + 4.3 ± 2.9 ml/kg per min, P<0.001; Powermax + 38 ± 7, P<0.001) exercise parameters and work efficiency (Powermax/V
O2peak + 1.3 ± 0.4 Power/ml per kg per min, P<0.001); there was also an inverse correlation between changes in NT-pro-BNP levels and in V
O2peak (r = −0.72, P<0.001), E-wave (r = −0.51, P<0.001) and E/A ratio (r = 0.59, P<0.001). In group B, at 3 months, no changes were observed in NT-pro-BNP levels, exercise and echocardiographic parameters.
Conclusion
Three months exercise training in patients with moderate left ventricular systolic dysfunction after myocardial infarction induced a reduction in NT-pro-BNP levels, an improvement of exercise capacity and early left ventricular diastolic filling, without negative left ventricular remodelling. Whether the reduction of NT-pro-BNP levels could be useful as a surrogate marker of favourable left ventricular remodelling at a later follow-up remains to be further explored.]]></description><identifier>ISSN: 2047-4873</identifier><identifier>ISSN: 1741-8267</identifier><identifier>EISSN: 2047-4881</identifier><identifier>DOI: 10.1097/01.hjr.0000209810.59831.f4</identifier><identifier>PMID: 16874155</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Biomarkers - blood ; Echocardiography, Doppler, Pulsed ; Exercise - physiology ; Exercise Therapy - methods ; Female ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - metabolism ; Heart Ventricles - physiopathology ; Humans ; Male ; Middle Aged ; Myocardial Contraction - physiology ; Myocardial Infarction - blood ; Myocardial Infarction - complications ; Myocardial Infarction - physiopathology ; Natriuretic Peptide, Brain - blood ; Treatment Outcome ; Ventricular Dysfunction, Left - blood ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - rehabilitation</subject><ispartof>European journal of cardiovascular prevention and rehabilitation, 2006-08, Vol.13 (4), p.625-632</ispartof><rights>2006 European Society of Cardiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e391f46cfcd3054c1cf37c2df9144d12ed56f7de4c38c3c6cc41eeb4264d36d13</citedby><cites>FETCH-LOGICAL-c417t-e391f46cfcd3054c1cf37c2df9144d12ed56f7de4c38c3c6cc41eeb4264d36d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16874155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giallauria, Francesco</creatorcontrib><creatorcontrib>Lorenzo, Anna De</creatorcontrib><creatorcontrib>Pilerci, Francesco</creatorcontrib><creatorcontrib>Manakos, Athanasio</creatorcontrib><creatorcontrib>Lucci, Rosa</creatorcontrib><creatorcontrib>Psaroudaki, Marianna</creatorcontrib><creatorcontrib>D'Agostino, Mariantonietta</creatorcontrib><creatorcontrib>Forno, Domenico Del</creatorcontrib><creatorcontrib>Vigorito, Carlo</creatorcontrib><title>Reduction of N terminal-pro-brain (B-type) natriuretic peptide levels with exercise-based cardiac rehabilitation in patients with left ventricular dysfunction after myocardial infarction</title><title>European journal of cardiovascular prevention and rehabilitation</title><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><description><![CDATA[Introduction
N-terminal-pro-brain (B-type) natriuretic peptide (NT-pro-BNP) is a peptide hormone released from ventricles in response to myocyte stretch. The aim of the study was to investigate the influence of exercise training on plasma NT-pro-BNP to verify if this parameter could be used as a biological marker of left ventricular remodelling in myocardial infarction patients undergoing an exercise training programme.
Methods
Forty-four patients after myocardial infarction were enrolled into a cardiac rehabilitation programme, and were randomized in two groups of 22 patients each. Group A patients followed a 3-month exercise training programme, while group B patients received only routine recommendations. All patients underwent NT-pro-BNP assay, and cardiopulmonary exercise test before hospital discharge and after 3 months.
Results
In Group A, exercise training reduced NT-pro-BNP levels (from 1498 ± 438 to 470 ± 375 pg/ml, P = 0.0026), increased maximal (V
O2peak + 4.3 ± 2.9 ml/kg per min, P<0.001; Powermax + 38 ± 7, P<0.001) exercise parameters and work efficiency (Powermax/V
O2peak + 1.3 ± 0.4 Power/ml per kg per min, P<0.001); there was also an inverse correlation between changes in NT-pro-BNP levels and in V
O2peak (r = −0.72, P<0.001), E-wave (r = −0.51, P<0.001) and E/A ratio (r = 0.59, P<0.001). In group B, at 3 months, no changes were observed in NT-pro-BNP levels, exercise and echocardiographic parameters.
Conclusion
Three months exercise training in patients with moderate left ventricular systolic dysfunction after myocardial infarction induced a reduction in NT-pro-BNP levels, an improvement of exercise capacity and early left ventricular diastolic filling, without negative left ventricular remodelling. Whether the reduction of NT-pro-BNP levels could be useful as a surrogate marker of favourable left ventricular remodelling at a later follow-up remains to be further explored.]]></description><subject>Biomarkers - blood</subject><subject>Echocardiography, Doppler, Pulsed</subject><subject>Exercise - physiology</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - metabolism</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Contraction - physiology</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Treatment Outcome</subject><subject>Ventricular Dysfunction, Left - blood</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - rehabilitation</subject><issn>2047-4873</issn><issn>1741-8267</issn><issn>2047-4881</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkc9uFSEUxomxsU3tKxjiwuhirjDDAONOG1tNmjZpdE0YOHi5Yf4ITPW-mk8nvXNjt7LhAN_vOyd8CL2mZENJJ94Tutnu4oaUVZNOluu2kw3dOPYMndWEiYpJSZ__q0Vzii5S2j0CnNS1lC_QKeVSMNq2Z-jPPdjFZD-NeHL4FmeIgx91qOY4VX3UfsRvP1V5P8M7POoc_RIhe4NnmLO3gAM8QEj4l89bDL8hGp-g6nUCi42O1muDI2x174PP-tCmOM6lgjEfsQAu44dyjt4sQUds98kt4zqUdmUiPOyn1S0U3Ol4eHuJTpwOCS6O-zn6fvX52-WX6ubu-uvlx5vKMCpyBU1HHePGGduQlhlqXCNMbV1HGbO0BttyJyww00jTGG4KBtCzmjPbcEubc_Rm9S1f8nOBlNXgk4EQ9AjTkhSXXLJO8CL8sApNnFKK4NQc_aDjXlGiHsNThKoSnnoKTx3CU44V-NWxy9IPYJ_QY1RFIFZB0j9A7aYllpjS_1j_Bf1frYk</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Giallauria, Francesco</creator><creator>Lorenzo, Anna De</creator><creator>Pilerci, Francesco</creator><creator>Manakos, Athanasio</creator><creator>Lucci, Rosa</creator><creator>Psaroudaki, Marianna</creator><creator>D'Agostino, Mariantonietta</creator><creator>Forno, Domenico Del</creator><creator>Vigorito, Carlo</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Reduction of N terminal-pro-brain (B-type) natriuretic peptide levels with exercise-based cardiac rehabilitation in patients with left ventricular dysfunction after myocardial infarction</title><author>Giallauria, Francesco ; Lorenzo, Anna De ; Pilerci, Francesco ; Manakos, Athanasio ; Lucci, Rosa ; Psaroudaki, Marianna ; D'Agostino, Mariantonietta ; Forno, Domenico Del ; Vigorito, Carlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-e391f46cfcd3054c1cf37c2df9144d12ed56f7de4c38c3c6cc41eeb4264d36d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biomarkers - blood</topic><topic>Echocardiography, Doppler, Pulsed</topic><topic>Exercise - physiology</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - metabolism</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Contraction - physiology</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Treatment Outcome</topic><topic>Ventricular Dysfunction, Left - blood</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - rehabilitation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giallauria, Francesco</creatorcontrib><creatorcontrib>Lorenzo, Anna De</creatorcontrib><creatorcontrib>Pilerci, Francesco</creatorcontrib><creatorcontrib>Manakos, Athanasio</creatorcontrib><creatorcontrib>Lucci, Rosa</creatorcontrib><creatorcontrib>Psaroudaki, Marianna</creatorcontrib><creatorcontrib>D'Agostino, Mariantonietta</creatorcontrib><creatorcontrib>Forno, Domenico Del</creatorcontrib><creatorcontrib>Vigorito, Carlo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cardiovascular prevention and rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giallauria, Francesco</au><au>Lorenzo, Anna De</au><au>Pilerci, Francesco</au><au>Manakos, Athanasio</au><au>Lucci, Rosa</au><au>Psaroudaki, Marianna</au><au>D'Agostino, Mariantonietta</au><au>Forno, Domenico Del</au><au>Vigorito, Carlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction of N terminal-pro-brain (B-type) natriuretic peptide levels with exercise-based cardiac rehabilitation in patients with left ventricular dysfunction after myocardial infarction</atitle><jtitle>European journal of cardiovascular prevention and rehabilitation</jtitle><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>13</volume><issue>4</issue><spage>625</spage><epage>632</epage><pages>625-632</pages><issn>2047-4873</issn><issn>1741-8267</issn><eissn>2047-4881</eissn><abstract><![CDATA[Introduction
N-terminal-pro-brain (B-type) natriuretic peptide (NT-pro-BNP) is a peptide hormone released from ventricles in response to myocyte stretch. The aim of the study was to investigate the influence of exercise training on plasma NT-pro-BNP to verify if this parameter could be used as a biological marker of left ventricular remodelling in myocardial infarction patients undergoing an exercise training programme.
Methods
Forty-four patients after myocardial infarction were enrolled into a cardiac rehabilitation programme, and were randomized in two groups of 22 patients each. Group A patients followed a 3-month exercise training programme, while group B patients received only routine recommendations. All patients underwent NT-pro-BNP assay, and cardiopulmonary exercise test before hospital discharge and after 3 months.
Results
In Group A, exercise training reduced NT-pro-BNP levels (from 1498 ± 438 to 470 ± 375 pg/ml, P = 0.0026), increased maximal (V
O2peak + 4.3 ± 2.9 ml/kg per min, P<0.001; Powermax + 38 ± 7, P<0.001) exercise parameters and work efficiency (Powermax/V
O2peak + 1.3 ± 0.4 Power/ml per kg per min, P<0.001); there was also an inverse correlation between changes in NT-pro-BNP levels and in V
O2peak (r = −0.72, P<0.001), E-wave (r = −0.51, P<0.001) and E/A ratio (r = 0.59, P<0.001). In group B, at 3 months, no changes were observed in NT-pro-BNP levels, exercise and echocardiographic parameters.
Conclusion
Three months exercise training in patients with moderate left ventricular systolic dysfunction after myocardial infarction induced a reduction in NT-pro-BNP levels, an improvement of exercise capacity and early left ventricular diastolic filling, without negative left ventricular remodelling. Whether the reduction of NT-pro-BNP levels could be useful as a surrogate marker of favourable left ventricular remodelling at a later follow-up remains to be further explored.]]></abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>16874155</pmid><doi>10.1097/01.hjr.0000209810.59831.f4</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals Online |
| subjects | Biomarkers - blood Echocardiography, Doppler, Pulsed Exercise - physiology Exercise Therapy - methods Female Heart Ventricles - diagnostic imaging Heart Ventricles - metabolism Heart Ventricles - physiopathology Humans Male Middle Aged Myocardial Contraction - physiology Myocardial Infarction - blood Myocardial Infarction - complications Myocardial Infarction - physiopathology Natriuretic Peptide, Brain - blood Treatment Outcome Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - rehabilitation |
| title | Reduction of N terminal-pro-brain (B-type) natriuretic peptide levels with exercise-based cardiac rehabilitation in patients with left ventricular dysfunction after myocardial infarction |
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