Effect of glycine on microcirculation in pial vessels of rat brain

Single application of glycine in a final dose of 40 mg/kg to the surface of the parietal area of rat brain produced a potent vasodilatory effect. The diameter of arterioles increased to 250% from the baseline level 1-3 min after treatment. These changes persisted for 5-10 min. In the follow-up perio...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2005-06, Vol.139 (6), p.675-677
Main Authors: Podoprigora, G I, Nartsissov, Ya R, Aleksandrov, P N
Format: Article
Language:English
Subjects:
Animals
Arterioles - drug effects
Brain - blood supply
Glycine - pharmacology
Male
Microcirculation - drug effects
Pia Mater - blood supply
Pia Mater - drug effects
Rats
Rats, Wistar
Time Factors
Vasodilation - drug effects
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Summary:Single application of glycine in a final dose of 40 mg/kg to the surface of the parietal area of rat brain produced a potent vasodilatory effect. The diameter of arterioles increased to 250% from the baseline level 1-3 min after treatment. These changes persisted for 5-10 min. In the follow-up period the diameter of vessels progressively decreased to the baseline level. Repeated application of glycine in the same dose also induced dilation of arterioles. Application of physiological saline under similar conditions did not produce these changes.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0375-2