Direct immunofluorescence in granuloma faciale: a case report and review of literature

:  A 49‐year‐old male presented at our department with erythematous brownish plaques in the malar areas and left cheek of 9 years' evolution. Histopathological study revealed a dense, predominantly perivascular, inflammatory infiltrate in the reticular dermis. The infiltrate was composed of abu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cutaneous pathology 2006-07, Vol.33 (7), p.508-511
Main Authors: Barnadas, M. A., Curell, R., Alomar, A.
Format: Article
Language:English
Subjects:
Complement System Proteins - metabolism
Face
Facial Dermatoses - drug therapy
Facial Dermatoses - immunology
Facial Dermatoses - pathology
Fluorescent Antibody Technique, Direct - methods
Granuloma - drug therapy
Granuloma - immunology
Granuloma - pathology
Humans
Immunoglobulins - metabolism
Immunosuppressive Agents - therapeutic use
Male
Middle Aged
Tacrolimus - therapeutic use
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary::  A 49‐year‐old male presented at our department with erythematous brownish plaques in the malar areas and left cheek of 9 years' evolution. Histopathological study revealed a dense, predominantly perivascular, inflammatory infiltrate in the reticular dermis. The infiltrate was composed of abundant neutrophils, lymphocytes, histiocytes, and eosinophils. Leukocytoclasia and fibrin in some vessel walls were also observed. The patient was diagnosed with granuloma faciale (GF). Direct immunofluorescence (DIF) study showed heavy immunoglobulin G (IgG) and less intense deposits of IgA, IgM, C3 and C1q surrounding superficial and deep vessels of the reticular dermis. Perivascular and diffuse fibrinogen deposits were also present. No deposits were detected at the dermoepidermal junction. Our findings lend support to the hypothesis that classical pathway activation of complement may be involved in the development of vasculitis in GF.
ISSN:0303-6987
1600-0560
DOI:10.1111/j.1600-0560.2006.00451.x