In vitro effects of gentamicin, ampicillin, and cefobid on energy supply and antioxidant protection systems of venous blood erythrocytes in newborns

We studied the effects of antibiotics of different classes on reserve capacities of the energy supply and antioxidant protection systems in newborns. Erythrocyte catalase activity was high in children with perinatal asphyxia. Penicillin antibiotics, aminoglycosides, and cephalosporins decreased enzy...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2005-06, Vol.139 (6), p.671-674
Main Authors: Sukoyan, G V, Mumladze, M R, Oboladze, E D, Varazanashvili, N A
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - biosynthesis
Ampicillin - pharmacology
Anti-Bacterial Agents - pharmacology
Antioxidants - pharmacology
Catalase - blood
Cefoperazone - pharmacology
Energy Metabolism - drug effects
Erythrocytes - enzymology
Gentamicins - pharmacology
Glutathione Peroxidase - blood
Glutathione Reductase - blood
Humans
Hydrogen Peroxide - pharmacology
Infant, Newborn
Reactive Oxygen Species - metabolism
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Summary:We studied the effects of antibiotics of different classes on reserve capacities of the energy supply and antioxidant protection systems in newborns. Erythrocyte catalase activity was high in children with perinatal asphyxia. Penicillin antibiotics, aminoglycosides, and cephalosporins decreased enzyme activity of the glutathione-associated antioxidant system. Ampicillin most significantly inhibited ATP synthesis in erythrocytes under conditions of hypoxia. Gentamicin was least potent in this respect. Impairment of ATP synthesis in erythrocytes was associated with inhibition of antioxidant enzymes catalase and glutathione reductase. Ampicillin increased glutathione peroxidase activity in response to addition of H2O2. None of the antibiotics modulated activity of cytosolic superoxide dismutase in blood erythrocytes from healthy newborns and newborns with perinatal asphyxia.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0374-3