An expedient synthesis of N6-substituted-5'-modified adenosines

Herein we report a short and efficient synthesis of N(6)-substituted 5'-modified adenosines, which was achieved in four steps from 2',3',5'-tris-O-(tert-butyldimethylsilyl)inosine.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2006-09, Vol.16 (17), p.4564-4566
Main Authors: ASHTON, T. D, SCAMMELLS, Peter J
Format: Article
Language:English
Subjects:
Adenosine - chemical synthesis
Adenosine - chemistry
Carbohydrates. Nucleosides and nucleotides
Chemistry
Exact sciences and technology
Inosine - chemistry
Molecular Structure
Nucleosides, nucleotides and oligonucleotides
Organic chemistry
Preparations and properties
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Description
Summary:Herein we report a short and efficient synthesis of N(6)-substituted 5'-modified adenosines, which was achieved in four steps from 2',3',5'-tris-O-(tert-butyldimethylsilyl)inosine.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.06.019