Synthesis and Biological Activity of Novel Acridinylidene and Benzylidene thiazolidinediones

A novel set of acridinylidene thiazolidinediones and benzylidene thiazolidinediones was synthesized by nucleophilic addition of cyanoacrylates. Some of these compounds were evaluated for their glucose lowering capability and their effects on the triglyceride level in alloxan diabetic mice.

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Bibliographic Details
Published in:European journal of medicinal chemistry 2005-11, Vol.40 (11), p.1129-1133
Main Authors: Mourão, R.H., Silva, T.G., Soares, A.L.M., Vieira, E.S., Santos, J.N., Lima, M.C.A., Lima, V.L.M., Galdino, S.L., Barbe, J., Pitta, I.R.
Format: Article
Language:English
Subjects:
Acridines - chemical synthesis
Acridines - chemistry
Acridines - pharmacology
Animals
Benzyl Compounds - chemical synthesis
Benzyl Compounds - chemistry
Benzyl Compounds - pharmacology
Biological and medical sciences
Blood Glucose - drug effects
Body Weight - drug effects
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - mortality
Drug Evaluation, Preclinical
Female
General and cellular metabolism. Vitamins
hypoglycaemic agents
Hypoglycemic Agents - chemical synthesis
Hypoglycemic Agents - pharmacology
Male
Medical sciences
Mice
Pharmacology. Drug treatments
Thiazolidinediones
Thiazolidinediones - chemical synthesis
Thiazolidinediones - chemistry
Thiazolidinediones - pharmacology
Triglycerides - blood
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Description
Summary:A novel set of acridinylidene thiazolidinediones and benzylidene thiazolidinediones was synthesized by nucleophilic addition of cyanoacrylates. Some of these compounds were evaluated for their glucose lowering capability and their effects on the triglyceride level in alloxan diabetic mice.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2005.06.002