Haplotype combination of Calpain-10 gene polymorphism is associated with metabolic syndrome in type 2 diabetes

• Published in: Diabetes research and clinical practice 2006-09, Vol.73 (3), p.268-275
• Main Authors: Kang, Eun Seok, Nam, Moonsuk, Kim, Hye Joo, Kim, Hyeong Jin, Myoung, Sung Min, Rhee, Yumie, Ahn, Chul Woo, Cha, Bong Soo, Lee, Hyun Chul
• Format: Article
• Language: English
• Subjects: Adult; Blood Glucose - analysis; Blood Pressure - physiology; Calpain - genetics; Calpain-10; Cholesterol, HDL - blood; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - physiopathology; Female; Gene Frequency; Genetic Predisposition to Disease - genetics; Genotype; Glycated Hemoglobin A - metabolism; Haplotype; Haplotypes - genetics; Humans; Korea; Male; Metabolic syndrome; Middle Aged; Odds Ratio; Polymorphism; Polymorphism, Single Nucleotide - genetics; Triglycerides - blood
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2006.01.011

Patients with metabolic syndrome are at increased risk of developing cardiovascular disease. The combinations of the haplotype created by the alleles of three single nucleotide polymorphisms (SNPs): SNP-43, -19, and -63 of the Calpain-10 gene ( CAPN10), have been reported to be associated with the risk of type 2 diabetes in many populations. The aim of this study was to examine the association of the CAPN10 polymorphism with metabolic syndrome in patients with type 2 diabetes in Korea. Overall, 382 patients with type 2 diabetes were enrolled in this study. All the subjects were genotyped according to CAPN10 SNP-43, -19, and -63. The restriction fragment length polymorphism method was used for the three SNPs. The baseline presence of components of metabolic syndrome was determined. Two hundred and sixty-five (69.4%) patients had metabolic syndrome. Patients with the 111/121 haplotype combination showed a higher risk of hypertension than the other haplotype combinations (odd ratio (OR) = 2.334, P = 0.010). Patients with the 111/121 haplotype combination had a significantly high risk of metabolic syndrome (OR = 1.927, P = 0.042). The results of this study suggest that a novel 111/121 haplotype combination created by the CAPN10 SNP-43, -19, and -63 increases the susceptibility to the metabolic syndrome in patients with type 2 diabetes.