Ventricular remodeling in Loeffler endocarditis: Implications for therapeutic decision making

Background: Little is known about the morphological and functional evolution of ventricular abnormalities in Loeffler endocarditis. Methods and Results: We describe 5 patients, including 3 with long‐term echocardiographic follow‐up, in whom apical obliteration due to fibro‐thrombotic thickening of t...

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Bibliographic Details
Published in:European journal of heart failure 2005-10, Vol.7 (6), p.1023-1026
Main Authors: Lofiego, Carla, Ferlito, Marinella, Rocchi, Guido, Biagini, Elena, Perugini, Enrica, Branzi, Angelo, Rapezzi, Claudio
Format: Article
Language:English
Subjects:
Adult
Decision Making
Disease Progression
Doppler echocardiography
Echocardiography, Doppler, Color - methods
Endomyocardial fibrosis
Female
Follow-Up Studies
Humans
Hypereosinophilia
Hypereosinophilic Syndrome - diagnostic imaging
Hypereosinophilic Syndrome - physiopathology
Hypereosinophilic Syndrome - therapy
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - physiopathology
Loeffler endocarditis
Male
Middle Aged
Risk Assessment
Sampling Studies
Severity of Illness Index
Thrombosis
Ventricular Function, Left - physiology
Ventricular Remodeling - physiology
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Summary:Background: Little is known about the morphological and functional evolution of ventricular abnormalities in Loeffler endocarditis. Methods and Results: We describe 5 patients, including 3 with long‐term echocardiographic follow‐up, in whom apical obliteration due to fibro‐thrombotic thickening of the endocardium showed favorable patterns of evolution. In one patient there was almost complete resolution of the obliterative process with consequently increased effective ventricular volume. In two patients formation of a flow‐passage in the fibrocalcific apical ‘floor’ between the main medioventricular cavity and the apical chamber, leading to a ‘double‐chambered’ left ventricle was observed. Conclusions: Medical therapy and appropriate anticoagulation, can induce favorable long‐term ventricular remodeling in Loeffler endocarditis.
ISSN:1388-9842
1879-0844
DOI:10.1016/j.ejheart.2005.06.004