Review article: an unexpected virus–host interaction – the hepatitis C virus‐diabetes link

Summary There is now consistent epidemiological evidence for an association between chronic hepatitis C and diabetes. Important, although so far limited longitudinal data, have documented an increased risk for diabetes in patients infected by hepatitis C virus (HCV) especially in those with metaboli...

Full description

Saved in:
Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2005-11, Vol.22 (s2), p.56-60
Main Authors: RATZIU, V., HEURTIER, A., BONYHAY, L., POYNARD, T., GIRAL, P.
Format: Article
Language:English
Subjects:
Blood Glucose - metabolism
Chronic Disease
Diabetes Mellitus - virology
Hepatitis C - complications
Hepatitis C virus
Humans
Insulin - metabolism
Insulin Resistance
Liver Cirrhosis - virology
Risk Factors
Signal Transduction - physiology
Viral Core Proteins - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary There is now consistent epidemiological evidence for an association between chronic hepatitis C and diabetes. Important, although so far limited longitudinal data, have documented an increased risk for diabetes in patients infected by hepatitis C virus (HCV) especially in those with metabolic risk factors such as a high BMI and older age. HCV encoded proteins might alter insulin signalling thus explaining impaired insulin sensitivity and the occurrence of glycaemic dysregulation even before the cirrhotic stage. The consequences of the association between diabetes and HCV infection are an increased liver fibrosis stage and faster fibrosis progression rate. This article reviews recent human and experimental data on the HCV‐diabetes association.
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2005.02598.x