Review article: an unexpected virus–host interaction – the hepatitis C virus‐diabetes link

Summary There is now consistent epidemiological evidence for an association between chronic hepatitis C and diabetes. Important, although so far limited longitudinal data, have documented an increased risk for diabetes in patients infected by hepatitis C virus (HCV) especially in those with metaboli...

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Published in:Alimentary pharmacology & therapeutics 2005-11, Vol.22 (s2), p.56-60
Main Authors: RATZIU, V., HEURTIER, A., BONYHAY, L., POYNARD, T., GIRAL, P.
Format: Article
Language:English
Subjects:
Blood Glucose - metabolism
Chronic Disease
Diabetes Mellitus - virology
Hepatitis C - complications
Hepatitis C virus
Humans
Insulin - metabolism
Insulin Resistance
Liver Cirrhosis - virology
Risk Factors
Signal Transduction - physiology
Viral Core Proteins - metabolism
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description Summary There is now consistent epidemiological evidence for an association between chronic hepatitis C and diabetes. Important, although so far limited longitudinal data, have documented an increased risk for diabetes in patients infected by hepatitis C virus (HCV) especially in those with metabolic risk factors such as a high BMI and older age. HCV encoded proteins might alter insulin signalling thus explaining impaired insulin sensitivity and the occurrence of glycaemic dysregulation even before the cirrhotic stage. The consequences of the association between diabetes and HCV infection are an increased liver fibrosis stage and faster fibrosis progression rate. This article reviews recent human and experimental data on the HCV‐diabetes association.
doi_str_mv 10.1111/j.1365-2036.2005.02598.x
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source Wiley-Blackwell Read & Publish Collection
subjects Blood Glucose - metabolism
Chronic Disease
Diabetes Mellitus - virology
Hepatitis C - complications
Hepatitis C virus
Humans
Insulin - metabolism
Insulin Resistance
Liver Cirrhosis - virology
Risk Factors
Signal Transduction - physiology
Viral Core Proteins - metabolism
title Review article: an unexpected virus–host interaction – the hepatitis C virus‐diabetes link
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