Keratinizing Squamous Epithelium Associated with Syringocystadenoma Papilliferum Differentiates towards Infrainfundibulum: Case Report with Immunohistochemical Study of Cytokeratins

We describe a case of Syringocystadenoma papilliferum (SCAP) with keratinizing squamous epithelium in a 26-year-old female presenting with a dark brown to black nodule on her forehead. After surgical excision, the specimen was examined immunohistochemically using antibodies against cytokeratin (CK)...

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Bibliographic Details
Published in:Journal of international medical research 2005-09, Vol.33 (5), p.590-593
Main Authors: Kurokawa, I, Mizutani, H, Nishijima, S, Kusumoto, K, Tsubura, A
Format: Article
Language:English
Subjects:
Adenoma, Sweat Gland - pathology
Adult
Epithelium - chemistry
Epithelium - pathology
Female
Humans
Keratins - analysis
Skin Neoplasms - pathology
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Summary:We describe a case of Syringocystadenoma papilliferum (SCAP) with keratinizing squamous epithelium in a 26-year-old female presenting with a dark brown to black nodule on her forehead. After surgical excision, the specimen was examined immunohistochemically using antibodies against cytokeratin (CK) 1, 8, 10, 14, 17, 18 and 19. Within the keratinizing squamous epithelium, CK1, 10, 14 and 17 were present, whereas the other CKs were absent. Based on CK expression, keratinizing squamous epithelium in SCAP seems to differentiate towards the infrainfundibulum.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323000503300515