Fluoxetine inhibits cortical spreading depression in weaned and adult rats suckled under favorable and unfavorable lactation conditions

• Published in: Experimental neurology 2006-08, Vol.200 (2), p.275-282
• Main Authors: dos Santos, Ângela Amâncio, Pinheiro, Patrícia Calado Ferreira, de Lima, Denise Sandrelly Cavalcanti, Ozias, Mirella Gondim, de Oliveira, Manuella Batista, Guimarães, Natália Xavier, Guedes, Rubem Carlos Araújo
• Format: Article
• Language: English
• Subjects: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents, Second-Generation - pharmacology; Biological and medical sciences; Body Weight - drug effects; Body Weight - physiology; Brain development; Cortical Spreading Depression - drug effects; Dose-Response Relationship, Drug; Early malnutrition; Electroencephalography - methods; Fluoxetine; Fluoxetine - pharmacology; Injuries of the nervous system and the skull. Diseases due to physical agents; Lactation - physiology; Malnutrition - physiopathology; Medical sciences; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; Organ Size - drug effects; Organ Size - physiology; Potassium Chloride - pharmacology; Rat; Rats; Rats, Wistar; Serotonin; Spreading depression; Time Factors; Traumas. Diseases due to physical agents; Weaning
• ISSN: 0014-4886; 1090-2430
• DOI: 10.1016/j.expneurol.2006.02.014

Wistar rats ( n = 58) were injected subcutaneously during the lactation period with fluoxetine (5, 10, 20 or 40 mg/kg/day) and cortical spreading depression (SD) was recorded immediately after weaning (25–30 days of life). An additional group (10 mg/kg; n = 8) was SD-recorded at 60–70 days. As compared to the saline-injected ( n = 24) or “ingenuous” ( n = 16) controls, fluoxetine dose-dependently reduced ( P