Expression of the zebrafish Iroquois genes during early nervous system formation and patterning

Iroquois genes are involved in many patterning processes during development. In particular, they act as prepattern genes to control proneural gene expression both in Drosophila and in vertebrates. In this paper, we have analyzed the expression during embryogenesis of the 11 zebrafish Iroquois genes,...

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Bibliographic Details
Published in:Journal of comparative neurology (1911) 2005-11, Vol.492 (3), p.289-302
Main Authors: Lecaudey, Virginie, Anselme, Isabelle, Dildrop, Renate, Rüther, Ulrich, Schneider-Maunoury, Sylvie
Format: Article
Language:English
Subjects:
Animals
Body Patterning
Central Nervous System - anatomy & histology
Central Nervous System - embryology
Cloning, Molecular
cranial placodes
Danio rerio
diencephalon
Drosophila
Embryonic Structures - anatomy & histology
Embryonic Structures - metabolism
Gene Expression Regulation, Developmental
hindbrain
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
homeodomain transcription factors
In Situ Hybridization
midbrain
Morphogenesis
Multigene Family
neurogenesis
Neurons - cytology
Neurons - metabolism
Protein Isoforms - genetics
Protein Isoforms - metabolism
Stem Cells - cytology
Stem Cells - metabolism
Teleostei
Zebrafish - embryology
Zebrafish - genetics
Zebrafish Proteins - genetics
Zebrafish Proteins - metabolism
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Summary:Iroquois genes are involved in many patterning processes during development. In particular, they act as prepattern genes to control proneural gene expression both in Drosophila and in vertebrates. In this paper, we have analyzed the expression during embryogenesis of the 11 zebrafish Iroquois genes, with special interest for nervous system formation and patterning. During the first 2 days of development, Iroquois genes are expressed in distinct domains in the neuroepithelium, as well as in groups of neuronal progenitors and neurons. They are also expressed at different stages of placodal development. These expression patterns are similar to the patterns of the murine irx genes and also show features specific to teleosts. For the zebrafish Iroquois gene family, we find both specific patterns and patterns conserved within a cluster, between paralogues, or in most genes of the family. Overall, these expression data suggest functions for the Iroquois family of transcription factors in neural and placodal patterning, neurogenesis, and neuronal specification. J. Comp. Neurol. 492:289–302, 2005. © 2005 Wiley‐Liss, Inc.
ISSN:0021-9967
1096-9861
DOI:10.1002/cne.20765