Two families with Greither's syndrome caused by a keratin 1 mutation

Transgrediens et progrediens palmoplantar keratoderma, known as Greither's syndrome, was originally described in 1952 and is characterized by diffuse keratoderma of the palms and soles, extending to the back aspects (transgrediens) and involving the skin over the Achilles' tendon. Patchy h...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2005-11, Vol.53 (5), p.S225-S230
Main Authors: Gach, Joanna E., Munro, Colin S., Lane, E. Birgitte, Wilson, Neil J., Moss, Celia
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Dermatology
Dyskeratosis
Female
Humans
Infant
Keratin-1
Keratins - genetics
Keratoderma, Palmoplantar - diagnosis
Keratoderma, Palmoplantar - genetics
Male
Medical sciences
Mutation, Missense
Pedigree
Syndrome
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Summary:Transgrediens et progrediens palmoplantar keratoderma, known as Greither's syndrome, was originally described in 1952 and is characterized by diffuse keratoderma of the palms and soles, extending to the back aspects (transgrediens) and involving the skin over the Achilles' tendon. Patchy hyperkeratosis also develops on the shins, knees, elbows, and sometimes on the skin flexures. We describe two unrelated families affected with Greither's syndrome, in which the same dominant missense mutation gave rise to the amino acid change N188S in K1. The previously reported cases of Greither's syndrome showed phenotypic variability suggestive of different underlying gene defects. Our findings suggest that at least some cases of Greither's syndrome are caused by keratin mutations.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2005.01.139