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Nanowires Network for Biomolecular Detection Using Contactless Impedance Tomoscopy Technique

Here we present the detection of ultralow concentrations of biomolecules in a device made from a polycarbonate membrane containing a network of gold nanowires and using a “contactless” impedance tomoscopy technique. The sensor comprises a thin dielectric layer with two parallel band electrodes on th...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2006-08, Vol.78 (15), p.5289-5295
Main Authors: Gamby, J, Abid, J.-P, Abid, M, Ansermet, J.-P, Girault, H. H
Format: Article
Language:English
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Summary:Here we present the detection of ultralow concentrations of biomolecules in a device made from a polycarbonate membrane containing a network of gold nanowires and using a “contactless” impedance tomoscopy technique. The sensor comprises a thin dielectric layer with two parallel band electrodes on the one side and a microchannel containing gold nanowires onto which the adsorption of antibodies occurs. Upon applying a high-frequency ac voltage between the two electrodes, the adsorption process occurring at the surface of the gold nanowires can be followed through contactless impedance measurements. The configuration allows the real-time detection of biomolecules with a bulk concentration in the picomolar range.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac060479z