Association between Genital Tract Cytomegalovirus Infection and Bacterial Vaginosis

Women with sexually transmitted diseases (STDs) and bacterial vaginosis (BV) have increased rates of cytomegalovirus (CMV) seroprevalence and CMV seroconversion. To characterize the association between genital tract CMV infection and BV, vaginal wash specimens from 52 women attending an STD clinic w...

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Bibliographic Details
Published in:The Journal of infectious diseases 2005-11, Vol.192 (10), p.1727-1730
Main Authors: Ross, Shannon A., Novak, Zdenek, Ashrith, Guha, Rivera, Lisa B., Britt, William J., Hedges, Spencer, Schwebke, Jane R., Boppana, and Suresh
Format: Article
Language:English
Subjects:
Adult
Bacteria
Bacterial vaginosis
Biological and medical sciences
Cytokines
Cytomegalovirus
Cytomegalovirus - classification
Cytomegalovirus - genetics
Cytomegalovirus - isolation & purification
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - epidemiology
Cytomegalovirus Infections - virology
DNA, Viral - analysis
Female
Fundamental and applied biological sciences. Psychology
Genitalia
Humans
Infections
Infectious diseases
Male
Medical sciences
Microbiology
Polymerase chain reaction
Sexual transmission
Sexually transmitted diseases
Vagina - virology
Vaginosis, Bacterial - complications
Vaginosis, Bacterial - epidemiology
Viral Envelope Proteins - genetics
Virus Shedding
Viruses
Women
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Description
Summary:Women with sexually transmitted diseases (STDs) and bacterial vaginosis (BV) have increased rates of cytomegalovirus (CMV) seroprevalence and CMV seroconversion. To characterize the association between genital tract CMV infection and BV, vaginal wash specimens from 52 women attending an STD clinic were analyzed. Significantly more women with BV shed CMV in the lower genital tract than did women without BV. In addition, most of the women who were shedding CMV were infected with >1 virus strain. These results suggest that local CMV replication and infection with multiple CMV strains is facilitated by the presence of BV
ISSN:0022-1899
1537-6613
DOI:10.1086/497150