Skeletal diversity construction via a branching synthetic strategy

A branching synthetic strategy was used to efficiently generate structurally diverse scaffolds, which span a broad area of chemical descriptor space, and their biological activity against MRSA was demonstrated.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2006-01 (31), p.3296-3298
Main Authors: Wyatt, Emma E, Fergus, Suzanne, Galloway, Warren R J D, Bender, Andreas, Fox, David J, Plowright, Alleyn T, Jessiman, Alan S, Welch, Martin, Spring, David R
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Methicillin Resistance
Staphylococcus aureus - drug effects
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Description
Summary:A branching synthetic strategy was used to efficiently generate structurally diverse scaffolds, which span a broad area of chemical descriptor space, and their biological activity against MRSA was demonstrated.
ISSN:1359-7345
1364-548X
DOI:10.1039/b607710b