Antibacterial and antioxidant activity of Sutherlandia frutescens (Fabaceae), a reputed anti-HIV/AIDS phytomedicine

Dried ground leaves of Sutherlandia frutescens were extracted by both sequential extraction with four solvents, starting with the least polar and separately with acetone, ethanol and water. The extracts were tested for antibacterial and antioxidant activity. The hexane extract was, generally, the mo...

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Bibliographic Details
Published in:Phytotherapy research 2005-09, Vol.19 (9), p.779-781
Main Authors: Katerere, D.R, Eloff, J.N
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - pharmacology
Anti-HIV Agents - therapeutic use
antibacterial
antioxidant
antioxidant, MIC
Antioxidants - administration & dosage
Antioxidants - pharmacology
Antioxidants - therapeutic use
Biological and medical sciences
Biphenyl Compounds
Escherichia - drug effects
Escherichia coli
Fabaceae
General pharmacology
Human immunodeficiency virus
Humans
Medical sciences
MIC
Microbial Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Picrates - chemistry
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
Staphylococcus aureus - drug effects
Sutherlandia frutescens
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Summary:Dried ground leaves of Sutherlandia frutescens were extracted by both sequential extraction with four solvents, starting with the least polar and separately with acetone, ethanol and water. The extracts were tested for antibacterial and antioxidant activity. The hexane extract was, generally, the most active extract against S. aureus, E. faecalis and E. coli with MIC values of 0.31, 1.25 and 2.50 mg/mL, respectively. The second method extracted compounds with antioxidant activity as shown by the DPPH free‐radical scavenging assay. The use of Sutherlandia frutescens for topical staphylococcal infections, when formulated in an oily base appears to have a rational basis. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1719