Lethal brain abscess due to the fungus Scedosporium apiospermum (teleomorph Pseudallescheria boydii) after a near-drowning incident: case report and review of the literature

A 39-year-old healthy man developed a brain abscess weeks after a near-drowning incident. Scedosporium apiospermum, the anamorph of Pseudallescheria boydii, was isolated from the abscess. The patient died 153 days after the accident despite antifungal therapy. We discuss the role of antifungals and...

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Bibliographic Details
Published in:Medical mycology (Oxford) 2006-08, Vol.44 (5), p.473-477
Main Authors: Buzina, W., Feierl, G., Haas, D., Reinthaler, F. F., Holl, A., Kleinert, R., Reichenpfader, B., Roll, P., Marth, E.
Format: Article
Language:English
Subjects:
Accidents, Traffic
Adolescent
Adult
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Brain Abscess - drug therapy
Brain Abscess - etiology
Brain Abscess - microbiology
Child
Child, Preschool
Fatal Outcome
Female
Humans
Infant
Male
Microbial Sensitivity Tests
Molecular Sequence Data
Mycetoma - drug therapy
Mycetoma - etiology
Mycetoma - microbiology
Near Drowning - complications
Pseudallescheria - isolation & purification
Pseudallescheria boydii
Pyrimidines - pharmacology
Pyrimidines - therapeutic use
Scedosporium - drug effects
Scedosporium - genetics
Scedosporium - isolation & purification
Scedosporium apiospermum
Telencephalon - microbiology
Triazoles - pharmacology
Triazoles - therapeutic use
Voriconazole
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Summary:A 39-year-old healthy man developed a brain abscess weeks after a near-drowning incident. Scedosporium apiospermum, the anamorph of Pseudallescheria boydii, was isolated from the abscess. The patient died 153 days after the accident despite antifungal therapy. We discuss the role of antifungals and review the literature for comparable cases.
ISSN:1369-3786
1460-2709
DOI:10.1080/13693780600654588