Efficacy of oral telithromycin in community-acquired pneumonia caused by resistant Streptococcus pneumoniae

The efficacy of oral telithromycin 800 mg once daily for 7 days was evaluated in a multicentre, multinational study in patients with community-acquired pneumonia caused by Streptococcus pneumoniae resistant to penicillin and/or erythromycin. Per-protocol clinical and bacteriological outcomes were as...

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Bibliographic Details
Published in:The Journal of infection 2005-10, Vol.51 (3), p.201-205
Main Authors: van Rensburg, Dirkie, Fogarty, Charles, De Salvo, María Cristina, Rangaraju, Manickam, Nusrat, Roomi
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotic resistance
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Biological and medical sciences
Community-Acquired Infections - drug therapy
Community-Acquired Infections - microbiology
Community-acquired pneumonia
Drug Resistance, Bacterial
Erythromycin - pharmacology
Female
Human bacterial diseases
Humans
Infectious diseases
Ketolides - administration & dosage
Ketolides - therapeutic use
Male
Medical sciences
Microbial Sensitivity Tests
Middle Aged
Penicillin Resistance
Penicillins - pharmacology
Pharmacology. Drug treatments
Pneumonia, Pneumococcal - drug therapy
Pneumonia, Pneumococcal - microbiology
Staphylococcal infections, streptococcal infections, pneumococcal infections
Streptococcus pneumoniae
Telithromycin
Treatment Outcome
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Description
Summary:The efficacy of oral telithromycin 800 mg once daily for 7 days was evaluated in a multicentre, multinational study in patients with community-acquired pneumonia caused by Streptococcus pneumoniae resistant to penicillin and/or erythromycin. Per-protocol clinical and bacteriological outcomes were assessed 10–17 days post-therapy. Of the 129 patients with S. pneumoniae infection, 16 were infected with strains resistant to penicillin and/or erythromycin. Fifteen of these 16 patients (93.8%) were assessed as clinically and bacteriologically cured at the post-therapy visit.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2004.11.004