Primary cryptococcal prostatitis and correlation with serum prostate specific antigen in a renal transplant recipient

The prostate gland is a rare site of primary infection due to Cryptococcus neoformans; however, it may serve as a site of its sequestration after an occult or treated disseminated infection. Serum prostate specific antigen may correlate with the severity of prostatic inflammation, but its role as a...

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Bibliographic Details
Published in:The Journal of infection 2005-10, Vol.51 (3), p.e153-e157
Main Authors: Siddiqui, Tahseen J., Zamani, Tanveer, Parada, Jorge P.
Format: Article
Language:English
Subjects:
Cryptococcosis - microbiology
Cryptococcus
Cryptococcus neoformans
Cryptococcus neoformans - isolation & purification
Fungemia - microbiology
Humans
Kidney Transplantation - adverse effects
Male
Middle Aged
Prostate specific antigen
Prostate-Specific Antigen - blood
Prostatitis
Prostatitis - microbiology
Transplant
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Summary:The prostate gland is a rare site of primary infection due to Cryptococcus neoformans; however, it may serve as a site of its sequestration after an occult or treated disseminated infection. Serum prostate specific antigen may correlate with the severity of prostatic inflammation, but its role as a diagnostic and prognostic marker is unclear. We report the first case of primary cryptococcal prostatitis in a renal transplant recipient. The diagnosis was established based on asymmetrically enlarged prostate gland, markedly elevated serum PSA levels, cryptococcal fungemia, an ultrasound-guided prostatic biopsy that demonstrated cryptococcal fungal elements and growth of C. neoformans on culture. The patient was successfully treated with a prolonged course of fluconazole and remained disease-free for more than 28 months of follow-up. In addition, we present a review of the published literature since 1946 and discuss possible correlation with PSA levels.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2004.12.005