LpA-I, LpA-I:A-II HDL and CHD-risk: The Framingham Offspring Study and the Veterans Affairs HDL Intervention Trial

• Published in: Atherosclerosis 2006-09, Vol.188 (1), p.59-67
• Main Authors: Asztalos, Bela F., Demissie, Serkalem, Cupples, L. Adrienne, Collins, Dorothea, Cox, Caitlin E., Horvath, Katalin V., Bloomfield, Hanna E., Robins, Sander J., Schaefer, Ernst J.
• Format: Article
• Language: English
• Subjects: ApoA-I; CHD-risk; Cholesterol, HDL - blood; Coronary Disease - epidemiology; HDL subpopulations; HDL-C; Humans; Lipoprotein(a) - blood; LpA-I; Male; Particle Size; Prevalence; Risk; United States; United States Department of Veterans Affairs
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2005.10.018

We tested the hypothesis that concentrations of LpA-I and/or LpA-I:A-II HDL subclasses are significantly associated with CHD prevalence and recurrent cardiovascular events. LpA-I levels were determined by differential electroimmunoassay in male participants with ( n = 169) and without CHD ( n = 850) from the Framingham Offspring Study (FOS) and in male participants with CHD from the placebo arm of the Veterans Affairs HDL Intervention Trial (VA-HIT) ( n = 741). Data were analyzed cross-sectionally (FOS) and prospectively (VA-HIT) and were adjusted for established lipid and non-lipid CHD risk factors. We observed slightly but significantly higher LpA-I levels in CHD cases compared to all or to HDL-C-matched controls and slightly but significantly higher LpA-I:A-II levels in CHD cases compared to HDL-C-matched controls it the FOS. Neither LpA-I nor LpA-I:A-II levels were significantly different between groups with and without recurrent cardiovascular events in the VA-HIT. No significant differences were observed in LpA-I and LpA-I:A-II levels in low HDL-C (≤40mg/dl) subjects with CHD (VA-HIT, n = 711) and without CHD (FOS, n = 373). Plasma LpA-I concentration had a positive correlation with the large LpA-I HDL particle (α-1) but no correlation with the small LpA-I HDL particle (preβ-1). LpA-I:A-II concentration had a positive correlation with the large (α-2) and an inverse correlation with the small (α-3) LpA-I:A-II HDL particles. Our data do not support the hypothesis that CHD prevalence (FOS) or recurrence of cardiovascular events (VA-HIT) are associated with significant reductions in the concentrations of LpA-I and/or LpA-I:A-II HDL subclasses.