Electroporation of transplantable tumour for the enhanced accumulation of photosensitizers

The aim of this study was to verify whether electroporation could increase the accumulation of the hydrophilic photosensitizers: aluminium phthalocyanine tetrasulphonate (AlPcS 4) and chlorin e 6 (C e 6) in tumour tissue. The experiment was performed in vivo using hybrid mice (C57Bl/CBA) bearing hep...

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Published in:Journal of photochemistry and photobiology. B, Biology Biology, 2005-11, Vol.81 (2), p.67-75
Main Authors: Tamošiūnas, M., Bagdonas, S., Didžiapetrienė, J., Rotomskis, R.
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Hepatocellular - metabolism
Chlorin
Electroporation
Electroporation - methods
Fluorescence
Indoles - pharmacokinetics
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Neoplasm Transplantation
Organometallic Compounds - pharmacokinetics
Photosensitizing Agents - pharmacokinetics
Phthalocyanine
Porphyrins - pharmacokinetics
Spectrometry, Fluorescence
Tumour
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Summary:The aim of this study was to verify whether electroporation could increase the accumulation of the hydrophilic photosensitizers: aluminium phthalocyanine tetrasulphonate (AlPcS 4) and chlorin e 6 (C e 6) in tumour tissue. The experiment was performed in vivo using hybrid mice (C57Bl/CBA) bearing hepatoma A22 (MH-A22) tumours transplanted in the right haunch. The time dependence of the fluorescence intensity of administered photosensitizers was measured after the ordinary and electrically stimulated delivery. The obtained fluorescence spectroscopy results implied the tumour being affected by an electrical field in a way, which led to a higher accumulation of both photosensitizers (AlPcS 4 and C e 6) in the periphery of the tumour and it superficial layer. Our pilot study suggests that electroporation could be considered as a useful procedure seeking for the more effective application of photodynamic tumour treatment.
ISSN:1011-1344
1873-2682
DOI:10.1016/j.jphotobiol.2005.05.009