Loading…
Distribution and determinants of serum high‐sensitive C‐reactive protein in a population of young adults. The Cardiovascular Risk in Young Finns Study
. Objectives. Elevated C‐reactive protein (CRP) is a suggested risk marker for cardiovascular disease. We aimed at investigating the distribution and determinants of CRP levels in young adults. Design. Population‐based study. Subjects. A total of 2120 participants aged 24–39 years. Main outcome m...
Saved in:
| Published in: | Journal of internal medicine 2005-11, Vol.258 (5), p.428-434 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4753-6bc4aadc9a5b54efec4d1de439aca88f0bfb2d95f0e01871bf80821e5c9b59543 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4753-6bc4aadc9a5b54efec4d1de439aca88f0bfb2d95f0e01871bf80821e5c9b59543 |
| container_end_page | 434 |
| container_issue | 5 |
| container_start_page | 428 |
| container_title | Journal of internal medicine |
| container_volume | 258 |
| creator | RAITAKARI, M. MANSIKKANIEMI, K. MARNIEMI, J. VIIKARI, J. S. A. RAITAKARI, O. T. |
| description | .
Objectives. Elevated C‐reactive protein (CRP) is a suggested risk marker for cardiovascular disease. We aimed at investigating the distribution and determinants of CRP levels in young adults.
Design. Population‐based study.
Subjects. A total of 2120 participants aged 24–39 years.
Main outcome measures. Distribution of CRP, and the relationship between CRP and risk factors.
Results. CRP concentration (mean ± SD) was 1.43 ± 3.26 mg L−1 in men, 1.36 ± 2.36 mg L−1 in women who did not use oral contraceptives (OC) and 3.69 ± 6.01 mg L−1 in women who used OCs. In total, 8.8% of men, 10.3% of non‐OC user women and 35.3% of OC user women had CRP concentration >3 mg L−1 (recommended cut‐off point of high risk for cardiovascular disease). In univariate analysis, CRP was associated with obesity indices and physical activity amongst both sexes. In men, the multivariate correlates of CRP included waist circumference (P |
| doi_str_mv | 10.1111/j.1365-2796.2005.01563.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68712683</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>924551261</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4753-6bc4aadc9a5b54efec4d1de439aca88f0bfb2d95f0e01871bf80821e5c9b59543</originalsourceid><addsrcrecordid>eNqNkdGO1CAUhonRuOPoKxhionetUAqFGxMzurpmzSa6XnhFKNAdxpbOQll37nwEr308n0Q6M3ETryQkcML3_zmcHwCIUYnzerkpMWG0qBrBygohWiJMGSlv74HF34f7YIEErQvGK3QCHsW4QQgTxNBDcIJZRThr-AL8euPiFFybJjd6qLyBxk42DM4rP0U4djDakAa4dlfr3z9-Ruujm9yNhatcBav0vtiGcbLOw7wV3I7b1Ku9X5bvxuSvoDKpn2IJL9dZqYJx442KOmMBfnLx2yz8ugdPnfcRfp6S2T0GDzrVR_vkeC7Bl9O3l6v3xfnFu7PV6_NC1w0lBWt1rZTRQtGW1razujbY2JoIpRXnHWq7tjKCdsgizBvcdhzxCluqRUvzgMgSvDj45l9cJxsnObiobd8rb8cUJcuiinGSwWf_gJsxBZ97k1g0omGkqTLED5AOY4zBdnIb3KDCTmIk5_DkRs4ZyTkjOYcn9-HJ2yx9evRP7WDNnfCYVgaeH4E8PNV3QXnt4h3XYEFZDnkJXh247663u_9uQH64OPs4X8kf7IO6ww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>197976372</pqid></control><display><type>article</type><title>Distribution and determinants of serum high‐sensitive C‐reactive protein in a population of young adults. The Cardiovascular Risk in Young Finns Study</title><source>Wiley</source><creator>RAITAKARI, M. ; MANSIKKANIEMI, K. ; MARNIEMI, J. ; VIIKARI, J. S. A. ; RAITAKARI, O. T.</creator><creatorcontrib>RAITAKARI, M. ; MANSIKKANIEMI, K. ; MARNIEMI, J. ; VIIKARI, J. S. A. ; RAITAKARI, O. T.</creatorcontrib><description>.
Objectives. Elevated C‐reactive protein (CRP) is a suggested risk marker for cardiovascular disease. We aimed at investigating the distribution and determinants of CRP levels in young adults.
Design. Population‐based study.
Subjects. A total of 2120 participants aged 24–39 years.
Main outcome measures. Distribution of CRP, and the relationship between CRP and risk factors.
Results. CRP concentration (mean ± SD) was 1.43 ± 3.26 mg L−1 in men, 1.36 ± 2.36 mg L−1 in women who did not use oral contraceptives (OC) and 3.69 ± 6.01 mg L−1 in women who used OCs. In total, 8.8% of men, 10.3% of non‐OC user women and 35.3% of OC user women had CRP concentration >3 mg L−1 (recommended cut‐off point of high risk for cardiovascular disease). In univariate analysis, CRP was associated with obesity indices and physical activity amongst both sexes. In men, the multivariate correlates of CRP included waist circumference (P < 0.0001), smoking (<0.0001) and HDL cholesterol (P = 0.024) (inverse association). These three variables explained 21.9% (model R2) of the total variation in CRP, waist circumference having the greatest influence (partial R2 = 19.6%). In women, the multivariate correlates of CRP included OC use (P < 0.0001), body mass index (BMI) (P < 0.0001), triglycerides (<0.0001) and physical activity (P = 0.025) (inverse association). These four variables explained 38.2% (model R2) of the total variation in CRP, with OC use (partial R2 = 18.4%) and BMI (partial R2 = 18.0%) having the greatest influence.
Conclusions. The determinants of CRP level include obesity and smoking in men, and obesity, OC use and physical activity in women. About one in three of healthy women who use OCs have CRP concentration exceeding 3 mg L−1.</description><identifier>ISSN: 0954-6820</identifier><identifier>EISSN: 1365-2796</identifier><identifier>DOI: 10.1111/j.1365-2796.2005.01563.x</identifier><identifier>PMID: 16238678</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Body Mass Index ; Body Size - physiology ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; cardiovascular ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cholesterol, HDL - blood ; Contraceptives, Oral - therapeutic use ; epidemiology ; Exercise - physiology ; Female ; Finland - epidemiology ; General aspects ; Humans ; inflammation ; Male ; Medical sciences ; Population Surveillance - methods ; Risk Factors ; Sex Distribution ; Smoking - blood ; Triglycerides - blood ; young adults</subject><ispartof>Journal of internal medicine, 2005-11, Vol.258 (5), p.428-434</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Nov 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4753-6bc4aadc9a5b54efec4d1de439aca88f0bfb2d95f0e01871bf80821e5c9b59543</citedby><cites>FETCH-LOGICAL-c4753-6bc4aadc9a5b54efec4d1de439aca88f0bfb2d95f0e01871bf80821e5c9b59543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17195601$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16238678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RAITAKARI, M.</creatorcontrib><creatorcontrib>MANSIKKANIEMI, K.</creatorcontrib><creatorcontrib>MARNIEMI, J.</creatorcontrib><creatorcontrib>VIIKARI, J. S. A.</creatorcontrib><creatorcontrib>RAITAKARI, O. T.</creatorcontrib><title>Distribution and determinants of serum high‐sensitive C‐reactive protein in a population of young adults. The Cardiovascular Risk in Young Finns Study</title><title>Journal of internal medicine</title><addtitle>J Intern Med</addtitle><description>.
Objectives. Elevated C‐reactive protein (CRP) is a suggested risk marker for cardiovascular disease. We aimed at investigating the distribution and determinants of CRP levels in young adults.
Design. Population‐based study.
Subjects. A total of 2120 participants aged 24–39 years.
Main outcome measures. Distribution of CRP, and the relationship between CRP and risk factors.
Results. CRP concentration (mean ± SD) was 1.43 ± 3.26 mg L−1 in men, 1.36 ± 2.36 mg L−1 in women who did not use oral contraceptives (OC) and 3.69 ± 6.01 mg L−1 in women who used OCs. In total, 8.8% of men, 10.3% of non‐OC user women and 35.3% of OC user women had CRP concentration >3 mg L−1 (recommended cut‐off point of high risk for cardiovascular disease). In univariate analysis, CRP was associated with obesity indices and physical activity amongst both sexes. In men, the multivariate correlates of CRP included waist circumference (P < 0.0001), smoking (<0.0001) and HDL cholesterol (P = 0.024) (inverse association). These three variables explained 21.9% (model R2) of the total variation in CRP, waist circumference having the greatest influence (partial R2 = 19.6%). In women, the multivariate correlates of CRP included OC use (P < 0.0001), body mass index (BMI) (P < 0.0001), triglycerides (<0.0001) and physical activity (P = 0.025) (inverse association). These four variables explained 38.2% (model R2) of the total variation in CRP, with OC use (partial R2 = 18.4%) and BMI (partial R2 = 18.0%) having the greatest influence.
Conclusions. The determinants of CRP level include obesity and smoking in men, and obesity, OC use and physical activity in women. About one in three of healthy women who use OCs have CRP concentration exceeding 3 mg L−1.</description><subject>Adult</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Body Mass Index</subject><subject>Body Size - physiology</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>cardiovascular</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cholesterol, HDL - blood</subject><subject>Contraceptives, Oral - therapeutic use</subject><subject>epidemiology</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>General aspects</subject><subject>Humans</subject><subject>inflammation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Population Surveillance - methods</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Smoking - blood</subject><subject>Triglycerides - blood</subject><subject>young adults</subject><issn>0954-6820</issn><issn>1365-2796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkdGO1CAUhonRuOPoKxhionetUAqFGxMzurpmzSa6XnhFKNAdxpbOQll37nwEr308n0Q6M3ETryQkcML3_zmcHwCIUYnzerkpMWG0qBrBygohWiJMGSlv74HF34f7YIEErQvGK3QCHsW4QQgTxNBDcIJZRThr-AL8euPiFFybJjd6qLyBxk42DM4rP0U4djDakAa4dlfr3z9-Ruujm9yNhatcBav0vtiGcbLOw7wV3I7b1Ku9X5bvxuSvoDKpn2IJL9dZqYJx442KOmMBfnLx2yz8ugdPnfcRfp6S2T0GDzrVR_vkeC7Bl9O3l6v3xfnFu7PV6_NC1w0lBWt1rZTRQtGW1razujbY2JoIpRXnHWq7tjKCdsgizBvcdhzxCluqRUvzgMgSvDj45l9cJxsnObiobd8rb8cUJcuiinGSwWf_gJsxBZ97k1g0omGkqTLED5AOY4zBdnIb3KDCTmIk5_DkRs4ZyTkjOYcn9-HJ2yx9evRP7WDNnfCYVgaeH4E8PNV3QXnt4h3XYEFZDnkJXh247663u_9uQH64OPs4X8kf7IO6ww</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>RAITAKARI, M.</creator><creator>MANSIKKANIEMI, K.</creator><creator>MARNIEMI, J.</creator><creator>VIIKARI, J. S. A.</creator><creator>RAITAKARI, O. T.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>Distribution and determinants of serum high‐sensitive C‐reactive protein in a population of young adults. The Cardiovascular Risk in Young Finns Study</title><author>RAITAKARI, M. ; MANSIKKANIEMI, K. ; MARNIEMI, J. ; VIIKARI, J. S. A. ; RAITAKARI, O. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4753-6bc4aadc9a5b54efec4d1de439aca88f0bfb2d95f0e01871bf80821e5c9b59543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>Body Mass Index</topic><topic>Body Size - physiology</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>cardiovascular</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cholesterol, HDL - blood</topic><topic>Contraceptives, Oral - therapeutic use</topic><topic>epidemiology</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Finland - epidemiology</topic><topic>General aspects</topic><topic>Humans</topic><topic>inflammation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Population Surveillance - methods</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Smoking - blood</topic><topic>Triglycerides - blood</topic><topic>young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RAITAKARI, M.</creatorcontrib><creatorcontrib>MANSIKKANIEMI, K.</creatorcontrib><creatorcontrib>MARNIEMI, J.</creatorcontrib><creatorcontrib>VIIKARI, J. S. A.</creatorcontrib><creatorcontrib>RAITAKARI, O. T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RAITAKARI, M.</au><au>MANSIKKANIEMI, K.</au><au>MARNIEMI, J.</au><au>VIIKARI, J. S. A.</au><au>RAITAKARI, O. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution and determinants of serum high‐sensitive C‐reactive protein in a population of young adults. The Cardiovascular Risk in Young Finns Study</atitle><jtitle>Journal of internal medicine</jtitle><addtitle>J Intern Med</addtitle><date>2005-11</date><risdate>2005</risdate><volume>258</volume><issue>5</issue><spage>428</spage><epage>434</epage><pages>428-434</pages><issn>0954-6820</issn><eissn>1365-2796</eissn><abstract>.
Objectives. Elevated C‐reactive protein (CRP) is a suggested risk marker for cardiovascular disease. We aimed at investigating the distribution and determinants of CRP levels in young adults.
Design. Population‐based study.
Subjects. A total of 2120 participants aged 24–39 years.
Main outcome measures. Distribution of CRP, and the relationship between CRP and risk factors.
Results. CRP concentration (mean ± SD) was 1.43 ± 3.26 mg L−1 in men, 1.36 ± 2.36 mg L−1 in women who did not use oral contraceptives (OC) and 3.69 ± 6.01 mg L−1 in women who used OCs. In total, 8.8% of men, 10.3% of non‐OC user women and 35.3% of OC user women had CRP concentration >3 mg L−1 (recommended cut‐off point of high risk for cardiovascular disease). In univariate analysis, CRP was associated with obesity indices and physical activity amongst both sexes. In men, the multivariate correlates of CRP included waist circumference (P < 0.0001), smoking (<0.0001) and HDL cholesterol (P = 0.024) (inverse association). These three variables explained 21.9% (model R2) of the total variation in CRP, waist circumference having the greatest influence (partial R2 = 19.6%). In women, the multivariate correlates of CRP included OC use (P < 0.0001), body mass index (BMI) (P < 0.0001), triglycerides (<0.0001) and physical activity (P = 0.025) (inverse association). These four variables explained 38.2% (model R2) of the total variation in CRP, with OC use (partial R2 = 18.4%) and BMI (partial R2 = 18.0%) having the greatest influence.
Conclusions. The determinants of CRP level include obesity and smoking in men, and obesity, OC use and physical activity in women. About one in three of healthy women who use OCs have CRP concentration exceeding 3 mg L−1.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16238678</pmid><doi>10.1111/j.1365-2796.2005.01563.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-6820 |
| ispartof | Journal of internal medicine, 2005-11, Vol.258 (5), p.428-434 |
| issn | 0954-6820 1365-2796 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68712683 |
| source | Wiley |
| subjects | Adult Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Body Mass Index Body Size - physiology C-Reactive Protein - analysis Cardiology. Vascular system cardiovascular Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cholesterol, HDL - blood Contraceptives, Oral - therapeutic use epidemiology Exercise - physiology Female Finland - epidemiology General aspects Humans inflammation Male Medical sciences Population Surveillance - methods Risk Factors Sex Distribution Smoking - blood Triglycerides - blood young adults |
| title | Distribution and determinants of serum high‐sensitive C‐reactive protein in a population of young adults. The Cardiovascular Risk in Young Finns Study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T23%3A33%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Distribution%20and%20determinants%20of%20serum%20high%E2%80%90sensitive%20C%E2%80%90reactive%20protein%20in%20a%20population%20of%20young%20adults.%20The%20Cardiovascular%20Risk%20in%20Young%20Finns%20Study&rft.jtitle=Journal%20of%20internal%20medicine&rft.au=RAITAKARI,%20M.&rft.date=2005-11&rft.volume=258&rft.issue=5&rft.spage=428&rft.epage=434&rft.pages=428-434&rft.issn=0954-6820&rft.eissn=1365-2796&rft_id=info:doi/10.1111/j.1365-2796.2005.01563.x&rft_dat=%3Cproquest_cross%3E924551261%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4753-6bc4aadc9a5b54efec4d1de439aca88f0bfb2d95f0e01871bf80821e5c9b59543%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=197976372&rft_id=info:pmid/16238678&rfr_iscdi=true |