Drug Utilization in the Pediatric Intensive Care Unit: Monitoring Prescribing Trends and Establishing Prioritization of Pharmacotherapeutic Evaluation of Critically Ill Children

The primary objective of this study was to characterize the drug exposure for children hospitalized in the authors’ institution's pediatric intensive care unit for the year 2002. Secondary objectives included the examination of drug utilization differences among various age criteria and the sui...

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Bibliographic Details
Published in:Journal of clinical pharmacology 2005-11, Vol.45 (11), p.1305-1312
Main Authors: Zuppa, Athena F., Adamson, Peter C., Mondick, John T., Davis, Lauren A., Maka, Deborah A., Narayan, Mahesh, Nicholson, Charles, Patel, Dimple, Collison, Kathryn R., Barrett, Jeffrey S.
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Child
Child, Preschool
Critically ill children
Drug Prescriptions - statistics & numerical data
Drug therapy
Drug Therapy - statistics & numerical data
Drug utililzation
Drug Utilization
Humans
Infant
Infant, Newborn
Intensive Care Units, Pediatric - standards
Intensive Care Units, Pediatric - statistics & numerical data
Management
Pediatric intensive care
Pediatric pharmacology
pharmacoepidemiology
Philadelphia
Practice Guidelines as Topic
prescribing practices
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Summary:The primary objective of this study was to characterize the drug exposure for children hospitalized in the authors’ institution's pediatric intensive care unit for the year 2002. Secondary objectives included the examination of drug utilization differences among various age criteria and the suitability of the most prevalent resources for pediatric dosing guidance. Many of the most commonly prescribed agents in the pediatric intensive care unit fall into the broad categories of pain management/sedation and anti‐infectives. Based on the generally narrow windows afforded by each of these drug classes, it is obvious that more, well‐defined investigations in critically ill children are warranted. The existing dosing guidance for many of these agents is neither generalizable nor sufficient to accommodate the diversity in pediatric intensive care unit patients, and the current drug monographs fall short of any practical dosing information.
ISSN:0091-2700
1552-4604
DOI:10.1177/0091270005280966