Cutting Edge: Macrophage Migration Inhibitory Factor Is Necessary for Progression of Experimental Autoimmune Encephalomyelitis

Macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of inflammatory and autoimmune diseases. The role of MIF in the progression of experimental autoimmune encephalomyelitis (EAE) was explored using MIF-/- mice. Wild-type mice showed a progressive disease course, wher...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2005-11, Vol.175 (9), p.5611-5614
Main Authors: Powell, Nicole D, Papenfuss, Tracey L, McClain, Melanie A, Gienapp, Ingrid E, Shawler, Todd M, Satoskar, Abhay R, Whitacre, Caroline C
Format: Article
Language:English
Subjects:
Animals
Cortisone - blood
Cytokines - biosynthesis
Disease Progression
Encephalomyelitis, Autoimmune, Experimental - blood
Encephalomyelitis, Autoimmune, Experimental - etiology
Glucocorticoids - antagonists & inhibitors
Macrophage Migration-Inhibitory Factors - physiology
Mice
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Summary:Macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of inflammatory and autoimmune diseases. The role of MIF in the progression of experimental autoimmune encephalomyelitis (EAE) was explored using MIF-/- mice. Wild-type mice showed a progressive disease course, whereas MIF-/- mice exhibited acute signs but no further progression of clinical disease. MIF-/- mice displayed markedly elevated corticosterone levels and significant decreases in the inflammatory cytokines TNF-alpha, IFN-gamma, IL-2, and IL-6 before, during, and after EAE onset. Taken together, these findings support that MIF is an important mediator of EAE progression through glucocorticoid antagonism and up-regulation of the inflammatory response.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.175.9.5611