Total antioxidant response in patients with schizophrenia

There is a large amount of convincing data demonstrating that reactive oxygen species (ROS) are involved in initiation and development of many different forms of neuropsychiatric disorders. The levels of oxidants and antioxidants in schizophrenia have been evaluated. However, measurements of total a...

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Published in:Psychiatry and clinical neurosciences 2006-08, Vol.60 (4), p.458-464
Main Authors: USTUNDAG, BILAL, ATMACA, MURAD, KIRTAS, OZLEM, SELEK, SAHABETTIN, METIN, KEREM, TEZCAN, ERTAN
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Antioxidants - metabolism
Biological and medical sciences
Female
Free Radicals
Humans
Male
Medical sciences
Middle Aged
paranoid
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
residual
Schizophrenia
Schizophrenia - blood
Schizophrenia - metabolism
Schizophrenic Psychology
Smoking - blood
Smoking - metabolism
total antioxidant response
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Summary:There is a large amount of convincing data demonstrating that reactive oxygen species (ROS) are involved in initiation and development of many different forms of neuropsychiatric disorders. The levels of oxidants and antioxidants in schizophrenia have been evaluated. However, measurements of total antioxidant response (TAR) were not evaluated up to now. Therefore, the objectives of this study are to investigate plasma TAR levels in schizophrenia subtypes. A total of 76 patients with schizophrenia and 25 healthy volunteers were included in the study. Positive and Negative Syndrome Scale (SANS and SAPS, respectively) were applied to patients. TAR values were determined in the plasma of normal healthy controls and patients with schizophrenia. Plasma TAR levels of each schizophrenia subtype were significantly lower than healthy controls (P 
ISSN:1323-1316
1440-1819
DOI:10.1111/j.1440-1819.2006.01532.x