The positive inotropic effect of the aqueous extract of Convallaria keiskei in beating rabbit atria

The positive inotropic effect of the aqueous extract of Convallaria keiskei (ACK) and the possible mechanisms responsible for this effect were investigated in beating rabbit atria. ACK significantly increased atrial stroke volume, pulse pressure, and cAMP efflux in beating rabbit atria. The effects...

Full description

Saved in:
Bibliographic Details
Published in:Life sciences (1973) 2006-08, Vol.79 (12), p.1178-1185
Main Authors: Choi, Deok Ho, Kang, Dae Gill, Cui, Xun, Cho, Kyung Woo, Sohn, Eun Jin, Kim, Jin Sook, Lee, Ho Sub
Format: Article
Language:English
Subjects:
Animals
Aqueous extract of Convallaria keiskei (ACK)
Cardiotonic Agents - pharmacology
Cardiovascular Agents - pharmacology
Convallaria - chemistry
Convallatoxin
Cyclic AMP - metabolism
Diltiazem - pharmacology
Dose-Response Relationship, Drug
Heart - drug effects
Heart Atria - drug effects
In Vitro Techniques
Inotropic effect
Male
Plant Extracts - pharmacology
Potassium - chemistry
Potassium - metabolism
Rabbits
Radioimmunoassay
Stroke Volume - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The positive inotropic effect of the aqueous extract of Convallaria keiskei (ACK) and the possible mechanisms responsible for this effect were investigated in beating rabbit atria. ACK significantly increased atrial stroke volume, pulse pressure, and cAMP efflux in beating rabbit atria. The effects were not altered by pre-treatment with staurosporine and diltiazem, a non-selective protein kinase inhibitor and an L-type Ca 2+ channel blocker, respectively. In addition, ACK markedly increased the K + concentration in the beating atria-derived perfusate. Convallatoxin, a well-known digitalis-like cardiac glycosidic constituent of ACK, also increased atrial stroke volume and pulse pressure but did not alter the cAMP efflux level. The increases in atrial stroke volume and pulse pressure induced by convallatoxin were not also altered by pre-treatment with diltiazem. These results suggest that the ACK-induced positive inotropic effect in beating rabbit atria may, at least in part, be due to the digitalis-like activity of convallatoxin.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2006.03.019