Novel selenoorganic compounds as modulators of oxidative stress in blood platelets

Many selenoorganic compounds play an important role in biochemical processes and act as antioxidants, enzyme inhibitors, or drugs. The effects of five new synthesized selenoorganic compounds (2-(5-chloro-2-pyridyl)-7-azabenzisoselenazol-3(2H)-one; 2-phenyl-7-azabenzisoselenazol-3(2H)-one; 2-(pyridyl...

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Bibliographic Details
Published in:Cell biology and toxicology 2006-09, Vol.22 (5), p.323-329
Main Authors: Saluk-Juszczak, J, Wachowicz, B, Wójtowicz, H, Kloc, K, Bald, E, Glowacki, R
Format: Article
Language:English
Subjects:
Antioxidants
Blood
Blood platelets
Blood Platelets - drug effects
Blood Platelets - metabolism
Enzyme inhibitors
Glutathione - metabolism
Humans
Medical research
Organoselenium Compounds - pharmacology
Oxidative stress
Oxidative Stress - drug effects
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Summary:Many selenoorganic compounds play an important role in biochemical processes and act as antioxidants, enzyme inhibitors, or drugs. The effects of five new synthesized selenoorganic compounds (2-(5-chloro-2-pyridyl)-7-azabenzisoselenazol-3(2H)-one; 2-phenyl-7-azabenzisoselenazol-3(2H)-one; 2-(pyridyl)-7-azabenzisoselenazol-3(2H)-one; 7-azabenzisoselenazol-3(2H)-one; bis(2-aminophenyl) diselenide) on oxidative changes in human blood platelets and in plasma were studied in vitro and compared with those of ebselen, a well known antioxidant. Our studies demonstrated that bis(2-aminophenyl) diselenide has distinctly protective effects against oxidative stress in blood platelets and in plasma. It might have greater biological relevance and stronger pharmacological effects than ebselen.
ISSN:0742-2091
1573-6822
DOI:10.1007/s10565-006-0091-3