Antidiarrhoeal activity of ethanol extract of the bark of Dalbergia lanceolaria

The bark of Dalbergia lanceolaria was undertaken for evaluation of antidiarrhoeal activity in albino mice based on ethnobotanical lead. This bark was collected from Khanapur area of Western Ghats near Pune, Maharashtra, India. The successive solvent extraction of bark was carried out after drying, u...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2005-11, Vol.102 (2), p.213-216
Main Authors: Mujumdar, A.M., Misar, A.V., Upadhye, A.S.
Format: Article
Language:English
Subjects:
Albino mice
Animals
Antidiarrheals - therapeutic use
Antidiarrhoeal activity
Barium chloride
Biological and medical sciences
Castor oil
Castor Oil - pharmacology
Charcoal meal
Dalbergia
Dalbergia lanceolaria bark
Diarrhea - drug therapy
Female
Gastrointestinal Transit - drug effects
General pharmacology
Intestinal Mucosa - drug effects
Intestinal Mucosa - secretion
Magnesium Sulfate - pharmacology
Magnesium sulphate
Male
Medical sciences
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - therapeutic use
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Summary:The bark of Dalbergia lanceolaria was undertaken for evaluation of antidiarrhoeal activity in albino mice based on ethnobotanical lead. This bark was collected from Khanapur area of Western Ghats near Pune, Maharashtra, India. The successive solvent extraction of bark was carried out after drying, using petroleum ether (60–80 °C) and ethanol in soxhlet apparatus. The ethanol extract showed activity against castor oil, magnesium sulphate induced diarrhoea in albino mice. The extract was also studied for castor oil induced intraluminal fluid accumulation as well as charcoal transit in normal and barium chloride treated animals. The extract reduced significantly intraluminal fluid accumulation and intestinal motility.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2005.06.014