Topical anti-inflammatory activity of Solenostemma argel leaves

The topical anti-inflammatory activity of Solenostemma argel Hayne leaves was evaluated using the Croton oil ear test in mice. A bioassay-guided fractionation procedure led to a highly active chloroform extract: at 300 μg/cm 2, it induced 73% oedema reduction, while the reference drug indomethacin (...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2005-11, Vol.102 (2), p.307-310
Main Authors: Innocenti, G., Dall’Acqua, S., Sosa, S., Altinier, G., Della Loggia, R.
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Anti-inflammatory Activity
Anti-Inflammatory Agents - pharmacology
Apocynaceae - chemistry
Asclepiadaceae
Biological and medical sciences
General pharmacology
Magnetic Resonance Spectroscopy
Male
Medical sciences
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - analysis
Plant Extracts - pharmacology
Plant Leaves - chemistry
Pregnene derivatives
Solenostemma argel
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Summary:The topical anti-inflammatory activity of Solenostemma argel Hayne leaves was evaluated using the Croton oil ear test in mice. A bioassay-guided fractionation procedure led to a highly active chloroform extract: at 300 μg/cm 2, it induced 73% oedema reduction, while the reference drug indomethacin (100 μg/cm 2) induced 56% reduction. The extract contained a new pregnene glycoside ( 1, solenoside A) and the known 14β,15α-dihydroxy-Δ 4pregnene-3,20 dione ( 2), kaempferol-3- O-glucoside ( 3) and kaempferol-3- O-rutinoside ( 4). Their structures were determined by ID and 2D NMR experiments as well as HRMS. Compounds 2 and 4 showed anti-inflammatory activity comparable to that of indomethacin.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2005.06.007