Evaluation of leptin level and Ob gene polymorphism in patients with Behcet's disease

The present study was aimed to evaluate serum leptin level and the frequency of oligopolymorphic codon 25 (CAA/CAG) of Ob gene in Behcet's disease. Eighty-seven patients with Behcet's disease and 85 healthy controls with matched age, gender and body mass index were included in the study. S...

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Bibliographic Details
Published in:Archives of Dermatological Research 2006-08, Vol.298 (3), p.127-130
Main Authors: OKUDAN, Nilsel, ACAR, Hasan, GÖKBEL, Hakki, MEVLITOGLU, Inci, SARI, Fatih
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Behcet Syndrome - blood
Behcet Syndrome - genetics
Biological and medical sciences
Case-Control Studies
Dermatology
Female
Humans
Leptin - blood
Leptin - genetics
Male
Medical sciences
Middle Aged
Polymorphism, Single Nucleotide
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:The present study was aimed to evaluate serum leptin level and the frequency of oligopolymorphic codon 25 (CAA/CAG) of Ob gene in Behcet's disease. Eighty-seven patients with Behcet's disease and 85 healthy controls with matched age, gender and body mass index were included in the study. Serum leptin level was determined and genotype of codon 25 of Ob gene was performed by using the PCR amplification after DNA extraction. Serum leptin concentration of the patients with Behcet's disease (23.8 +/- 22.8 ng/ml) was higher than that of the control groups (17.1 +/- 14.7 ng/ml). The patients with Behcet's disease and control subjects showed CAA/CAA genotype, indicating the presence of no polymorphism. Neither Behcet's disease nor serum leptin level was found to be related to codon 25 polymorphism. We concluded that leptin 25CAG polymorphism is not associated with Behcet's disease and serum leptin level.
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-006-0669-x