Advanced clear-cell adenocarcinoma of the bladder successfully treated by radical surgery with adjuvant chemoradiotherapy

A 52-year-old woman was referred to our institute for the evaluation of a tumor in her pelvic cavity. The tumor seemed to have arisen from the bladder or urethra, and bilateral iliac lymphadenopathy was seen. Her urethral mucosa looked intact according to the results of cystourethroscopy. Histopatho...

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Bibliographic Details
Published in:International journal of clinical oncology 2005-10, Vol.10 (5), p.362-365
Main Authors: Kurosaka, Shinji, Irie, Akira, Mizoguchi, Hideyuki, Okuno, Norihiko, Iwabuchi, Keiichi, Baba, Shiro
Format: Article
Language:English
Subjects:
Adenocarcinoma, Clear Cell - drug therapy
Adenocarcinoma, Clear Cell - pathology
Adenocarcinoma, Clear Cell - surgery
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer
Cells
Chemotherapy
Chemotherapy, Adjuvant
Cystectomy
Female
Humans
Lymph Node Excision
Lymphatic system
Middle Aged
Pelvis
Surgery
Tumors
Urethra - surgery
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - surgery
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Summary:A 52-year-old woman was referred to our institute for the evaluation of a tumor in her pelvic cavity. The tumor seemed to have arisen from the bladder or urethra, and bilateral iliac lymphadenopathy was seen. Her urethral mucosa looked intact according to the results of cystourethroscopy. Histopathological examination of the biopsy specimens showed clear-cell adenocarcinoma. She underwent radical cystourethrectomy with complete pelvic lymph node dissection and the construction of a bilateral ureterocutaneostomy. Macroscopically, the tumor had arisen from the trigone of the bladder, and histopathological examination of the tumor revealed adenocarcinoma exhibiting solid clear cells with glandular and papillary patterns. The tumor had infiltrated perivesical structure (pT3a), and metastases in multiple pelvic lymph nodes were recognized (pN3). Postoperatively, three courses of systemic combination chemotherapy with 5-fluouracil (FU) and cisplatin, along with a total of 45 Gy of irradiation during the second course of chemotherapy, were conducted. No evidence of the disease has been seen 28 months after the surgery.
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-005-0497-6