Molecular regulation of adult CNS neurogenesis: an integrated view

Neural stem cells in the adult subventricular zone and dentate gyrus might be utilized to replace lost neurons in neurological disorders. The development of treatments would be facilitated by identifying the mechanisms that contribute to functional neurogenesis in adult animals. This review focuses...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2005-11, Vol.28 (11), p.589-595
Main Author: Hagg, Theo
Format: Article
Language:English
Subjects:
Adult
Animals
Astrocytes - secretion
Biological and medical sciences
Cell Differentiation - physiology
Cell Movement - physiology
Cell Proliferation
Cell Survival - physiology
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Humans
Lateral Ventricles - cytology
Mammals
Middle Aged
Molecular biology
Nerve Growth Factors - physiology
Nerve Growth Factors - secretion
Nervous system
Neurons - cytology
Neurons - physiology
Neurosciences
Prosencephalon - cytology
Stem Cells - cytology
Stem Cells - physiology
Vertebrates: nervous system and sense organs
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Summary:Neural stem cells in the adult subventricular zone and dentate gyrus might be utilized to replace lost neurons in neurological disorders. The development of treatments would be facilitated by identifying the mechanisms that contribute to functional neurogenesis in adult animals. This review focuses on the emerging view that localized and overlapping pathways of growth factors, metalloproteases, neurotransmitters and hormones regulate different aspects of neurogenesis within the neurogenic niches. Neuroblast migration is precisely regulated by cooperation between several repellants, attractants and guidance molecules that are located within specific CNS regions. Further elucidation of crucial molecular regulators and integration of their signaling cascades should lead to more rational and effective approaches to harness the exciting phenomenon of adult CNS neurogenesis.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2005.08.009