Notch signaling in hematopoiesis and lymphopoiesis: Lessons from Drosophila

The evolutionarily conserved Notch signaling pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. It is involved in embryonic organogenesis as well as in the maintenance of homeostasis of self‐renewing systems. In this article, we r...

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Bibliographic Details
Published in:BioEssays 2005-11, Vol.27 (11), p.1117-1128
Main Authors: Radtke, Freddy, Wilson, Anne, MacDonald, H. Robson
Format: Article
Language:English
Subjects:
Animals
Drosophila
Drosophila - cytology
Drosophila - embryology
Drosophila - growth & development
Drosophila - metabolism
Hematopoiesis
Humans
Receptors, Notch - genetics
Receptors, Notch - metabolism
Signal Transduction
Stem Cells - cytology
Stem Cells - metabolism
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Summary:The evolutionarily conserved Notch signaling pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. It is involved in embryonic organogenesis as well as in the maintenance of homeostasis of self‐renewing systems. In this article, we review the role of Notch signaling in the hematopoietic system with particular emphasis on lymphocyte development and highlight the similarities in Notch function between Drosophila and mammalian differentiation processes. Recent studies indicating that aberrant NOTCH signaling is frequently linked to the induction of T leukemia in humans will also be discussed. BioEssays 27:1117–1128, 2005. © 2005 Wiley Periodicals, Inc.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.20315