CXC chemokines in angiogenesis

CXC chemokines display pleiotropic effects in immunity, regulating angiogenesis, and mediating organ-specific metastases of cancer. In the context of angiogenesis, CXC chemokines are a unique family of cytokines, known for their ability to behave in a disparate manner in the regulation of angiogenes...

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Bibliographic Details
Published in:Cytokine & growth factor reviews 2005-12, Vol.16 (6), p.593-609
Main Authors: Strieter, Robert M., Burdick, Marie D., Gomperts, Brigitte N., Belperio, John A., Keane, Michael P.
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis Modulating Agents - pharmacology
Angiostasis
Animals
Chemokines
Chemokines, CXC - analysis
Chemokines, CXC - physiology
Fibroproliferation
Humans
Immune System Diseases - etiology
Inflammation
Neovascularization, Physiologic - drug effects
Neovascularization, Physiologic - physiology
Receptors, Chemokine - metabolism
T-Lymphocytes - immunology
Tumorgenesis
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Summary:CXC chemokines display pleiotropic effects in immunity, regulating angiogenesis, and mediating organ-specific metastases of cancer. In the context of angiogenesis, CXC chemokines are a unique family of cytokines, known for their ability to behave in a disparate manner in the regulation of angiogenesis. Members that contain the ‘ELR’ motif are potent promoters of angiogenesis, and mediate their angiogenic activity via binding and activating CXCR2 on endothelium. In contrast, members, in general, those are inducible by interferons and lack the ELR motif (ELR −) are potent inhibitors of angiogenesis, and bind to CXCR3 on endothelium. This review will discuss the biology of these angiogenic and angiostatic CXC chemokines and discuss their disparate angiogenic activity in the context of a variety of disorders.
ISSN:1359-6101
DOI:10.1016/j.cytogfr.2005.04.007