The role of auxiliary dihydropyridine receptor subunits in muscle

The skeletal muscle dihydropyridine receptor is a slowly-activating calcium channel that functions as the voltage sensor in excitation-contraction coupling. In addition to the pore-forming alpha(1S) subunit it contains the transmembrane alpha(2)delta-1 and gamma(1) subunits and the cytoplasmic beta(...

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Bibliographic Details
Published in:Journal of muscle research and cell motility 2005-02, Vol.26 (1), p.1-6
Main Authors: Flucher, Bernhard E, Obermair, Gerald J, Tuluc, Petronel, Schredelseker, Johann, Kern, Georg, Grabner, Manfred
Format: Article
Language:English
Subjects:
Animals
Calcium Channels, L-Type - genetics
Calcium Channels, L-Type - physiology
Muscle, Skeletal - physiology
Protein Subunits - genetics
Protein Subunits - physiology
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Summary:The skeletal muscle dihydropyridine receptor is a slowly-activating calcium channel that functions as the voltage sensor in excitation-contraction coupling. In addition to the pore-forming alpha(1S) subunit it contains the transmembrane alpha(2)delta-1 and gamma(1) subunits and the cytoplasmic beta(1a) subunit. Although the roles of the auxiliary subunits in calcium channel function have been intensively studied in heterologous expression systems, their functions in excitation-contraction coupling has only recently been elucidated in muscle cells of various null-mutant animal models. In this article we will briefly outline the current state of these investigations.
ISSN:0142-4319
1573-2657
DOI:10.1007/s10974-005-9000-2