Anatomical, histological and genetic investigations of a sexually anomalous goat

An apparently female goat was masculine in appearance and had strong male-pattern libido and behaviour. The goat’s DNA was subjected to PCR analysis and its reproductive system was examined anatomically and histologically. The external genitalia consisted of an apparent vulva in the normal position...

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Bibliographic Details
Published in:Veterinary record 2005-10, Vol.157 (17), p.513-516
Main Authors: Hafez, S. A., Huckle, W. R., Caceci, T.
Format: Article
Language:English
Subjects:
Animals
Diagnosis, Differential
Disorders of Sex Development - diagnosis
Disorders of Sex Development - pathology
Disorders of Sex Development - veterinary
Female
genetic techniques and protocols
Goat Diseases - diagnosis
Goat Diseases - pathology
Goats
Polymerase Chain Reaction - veterinary
Sex Determination Analysis - veterinary
sexing
Y Chromosome - chemistry
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Summary:An apparently female goat was masculine in appearance and had strong male-pattern libido and behaviour. The goat’s DNA was subjected to PCR analysis and its reproductive system was examined anatomically and histologically. The external genitalia consisted of an apparent vulva in the normal position and a grossly enlarged clitoris. Two masses could be palpated lying subcutaneously in the inguinal region; when they were removed they had the macroscopic appearance of hypoplastic testes, and histologically they had atrophic tubules and prominent interstitial tissues. To exclude sex chimaerism, X and Y chromosome-specific targets were amplified by PCR, using bone marrow and muscle DNA templates. The goat had some Y chromosomespecific sequences such as SRY and BRY.I but lacked others, such as BOV97M.
ISSN:0042-4900
2042-7670
DOI:10.1136/vr.157.17.513