Enantioselective Alkylation of Aldehydes Catalyzed by a Highly Active Titanium Complex of 3-Substituted Unsymmetric BINOL

A titanium complex derived from 3-(3,5-diphenylphenyl)-BINOL exhibits an enhanced catalytic activity in the asymmetric alkylation of aldehydes, allowing the reduction of the catalyst amount to less than 1 mol % without deterioration in enantioselectivity.

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Bibliographic Details
Published in:Organic letters 2006-08, Vol.8 (17), p.3817-3819
Main Authors: Harada, Toshiro, Kanda, Kousou
Format: Article
Language:English
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Summary:A titanium complex derived from 3-(3,5-diphenylphenyl)-BINOL exhibits an enhanced catalytic activity in the asymmetric alkylation of aldehydes, allowing the reduction of the catalyst amount to less than 1 mol % without deterioration in enantioselectivity.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol061407x