Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology

Analytical characteristics of DESI are summarized. Examples of applications to small and large molecules, to in situ analysis, and to high‐throughput analyses are presented. Evidence is provided for both a heterogeneous charge‐transfer mechanism and a droplet pick‐up mechanism of ionization. The spe...

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Bibliographic Details
Published in:Journal of mass spectrometry. 2005-10, Vol.40 (10), p.1261-1275
Main Authors: Takáts, Zoltán, Wiseman, Justin M., Cooks, R. Graham
Format: Article
Language:English
Subjects:
Analytical chemistry
Animals
Biological Products - analysis
Biological Products - chemistry
Biological Science Disciplines - methods
chemical profiling
Chemistry
Chemistry Techniques, Analytical - methods
desorption ionization
electrospray ionization
Exact sciences and technology
Forensic Sciences - methods
high throughput
Humans
in situ analysis
in vivo analysis
ionization mechanisms
metabolomics
natural products
Spectrometric and optical methods
Spectrometry, Mass, Electrospray Ionization - instrumentation
Spectrometry, Mass, Electrospray Ionization - methods
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Summary:Analytical characteristics of DESI are summarized. Examples of applications to small and large molecules, to in situ analysis, and to high‐throughput analyses are presented. Evidence is provided for both a heterogeneous charge‐transfer mechanism and a droplet pick‐up mechanism of ionization. The speed, lack of the need for sample preparation, selectivity, and sensitivity of DESI are all demonstrated and discussed. Instrumentation is also discussed. Forensic applications as well as emerging areas of application including tissue imaging are given emphasis. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:1076-5174
1096-9888
DOI:10.1002/jms.922