Role of Mitogen‐Activated Protein (MAP) Kinases in Cardiovascular Diseases

ABSTRACT Over the last decade important advances have been made in our understanding of the molecular events underlying cellular responses to extracellular signals. Increased understanding of signal transduction mechanisms and gene regulation involved in cardiovascular diseases has created opportuni...

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Bibliographic Details
Published in:Cardiovascular drug reviews 2005-09, Vol.23 (3), p.247-254
Main Authors: Pandya, Nilesh, Santani, Dev, Jain, Sunita
Format: Article
Language:English
Subjects:
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiomyopathy
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - enzymology
Cardiovascular Diseases - physiopathology
Cardiovascular system
Heart
Humans
MAP kinase
MAP Kinase Signaling System - drug effects
Medical sciences
Mitogen-Activated Protein Kinases - antagonists & inhibitors
Mitogen-Activated Protein Kinases - metabolism
Mitogen-Activated Protein Kinases - physiology
Myocardial contractility
Myocarditis. Cardiomyopathies
Pharmacology. Drug treatments
Technology, Pharmaceutical - methods
Technology, Pharmaceutical - trends
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Summary:ABSTRACT Over the last decade important advances have been made in our understanding of the molecular events underlying cellular responses to extracellular signals. Increased understanding of signal transduction mechanisms and gene regulation involved in cardiovascular diseases has created opportunities for the discovery of novel therapeutic compounds useful for the treatment of cardiovascular disorders. One of the best‐studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway, which plays a crucial role in many aspects of cardiovascular responses. Here, our current understanding of the MAP kinase pathway is reviewed, as well as recent advances in the design of novel agents that are able to modulate the activity of these signaling cascades.
ISSN:0897-5957
1527-3466
DOI:10.1111/j.1527-3466.2005.tb00169.x