Reparative osteogenesis during transplantation of mesenchymal stem cells

Reparative osteogenesis was studied after xenotransplantation of suspension cell graft from human mesenchymal stem cells. A model of experimental damage to rat femoral diaphysis was developed. The state of animals was satisfactory and non-depressed in the early and late postoperation period. We reve...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2005-07, Vol.140 (1), p.96-99
Main Authors: Fatkhudinov, T Kh, Goldshtein, D V, Pulin, A A, Shamenkov, D A, Rzhaninova, A A, Gornostaeva, S A, Grigor'yan, A S, Kulakov, A A
Format: Article
Language:English
Subjects:
Animals
Diaphyses - injuries
Femur - injuries
Histological Techniques
Humans
Mesenchymal Stem Cell Transplantation
Osteogenesis - physiology
Rats
Regeneration - physiology
Transplantation, Heterologous
Wound Healing - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Reparative osteogenesis was studied after xenotransplantation of suspension cell graft from human mesenchymal stem cells. A model of experimental damage to rat femoral diaphysis was developed. The state of animals was satisfactory and non-depressed in the early and late postoperation period. We revealed no local pathological reactions and complications. Administration of mesenchymal stem cells into the area of bone defect accelerated and improved regeneration. Unilateral transplantation of the cell graft stimulated regeneration in the contralateral limb due to acceleration of bone tissue maturation. On day 90 after treatment the bone regenerate was completely developed in the area of defect in animals of various groups. The newly formed bone tissue was well integrated into the bone organ.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0421-0