Germinal matrix cells associate with veins and a glial scaffold in the human fetal brain

Germinal matrix (GM) in the subventricular zone (SVZ) includes progenitor cells of neurons and glia, which migrate from the SVZ to regions where they become integrated into the developing brain. In the human fetal brain, GM cells pack into high density clusters that encircle GM veins producing a pro...

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Bibliographic Details
Published in:Brain research. Developmental brain research 2005-11, Vol.160 (1), p.96-100
Main Authors: Anstrom, John A., Thore, Clara R., Moody, Dixon M., Challa, Venkata R., Block, Steven M., Brown, William R.
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Astrocyte
Astrocytes - cytology
Astrocytes - metabolism
Brain
Brain - blood supply
Brain - cytology
Brain - embryology
Cell Differentiation - physiology
Cell Movement - physiology
Female
Fetus - cytology
Fetus - embryology
Germinal matrix
Glial Fibrillary Acidic Protein
Humans
Migration
Models, Biological
Neovascularization, Physiologic - physiology
Neurons - cytology
Neurons - physiology
Pregnancy
Stem Cells - cytology
Stem Cells - physiology
Vein
Veins - cytology
Veins - embryology
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Summary:Germinal matrix (GM) in the subventricular zone (SVZ) includes progenitor cells of neurons and glia, which migrate from the SVZ to regions where they become integrated into the developing brain. In the human fetal brain, GM cells pack into high density clusters that encircle GM veins producing a profile we describe as a venous cuff. Venous cuffs are, in turn, encircled by GFAP-positive astrocytes that project processes through the cuff to the venous wall. The high cell density exhibited by cuffs, as well as their association with astrocytes, are reminiscent of features associated with chain migration. However, chain migration has not been associated previously with veins. We suggest that the GM cuff cells may represent a distinct subset of GM cells that migrate away from the GM on a pathway consisting of a vein and its associated astrocytic scaffold.
ISSN:0165-3806
DOI:10.1016/j.devbrainres.2005.07.016